ID M3Z3G9_MUSPF Unreviewed; 780 AA.
AC M3Z3G9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A4 {ECO:0000313|Ensembl:ENSMPUP00000018131.1,
GN ECO:0000313|RefSeq:XP_004739586.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018131.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018131.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004739586.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004739586.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AEYP01005323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01005324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004739586.1; XM_004739529.2.
DR RefSeq; XP_004739587.1; XM_004739530.2.
DR STRING; 9669.ENSMPUP00000018131; -.
DR Ensembl; ENSMPUT00000018397.1; ENSMPUP00000018131.1; ENSMPUG00000018245.1.
DR GeneID; 101677515; -.
DR KEGG; mpuf:101677515; -.
DR CTD; 5172; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR OMA; WKQNKTD; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0015111; F:iodide transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 105..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 186..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 247..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 300..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 350..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 385..408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 420..438
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 479..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 535..729
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 780 AA; 85900 MW; C56E3101C24881A2 CRC64;
MEAPGSRLEP PPLPEYSCSY VVSRPVYSEL AFQQQYERRL QERKTLRESL AKGCSCSRKR
GLGVLKTLLP VLDWLPKYRI KEWLLSDIIS GVSTGLVGTL QGMAYALLAA VPVGYGLYSA
FFPILTYFIF GTSRHISVGP FPVVSLMVGS VVLSMAPDEH FRVSSSNGTA FNTTVIDYVA
RDTARVLIAS TLTLLVGIIQ LIFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL
NVSTKNYNGV LSIIYTLIEI FQNVGNTNLA DFIAGLLTII ICMAVKEVND RFKHKIPVPI
PIEVIVTIIA TAISYGADLE KNYNAGIVKS IPRGFLPPIL PPVSLFSEML AASFSIAVVA
YAIAVSVGKV YAIKYDYTID GNQEFIAFGI SNIFSGFFSC FVATTALSRT AVQESTGGKT
QIAGIISAGI VMIAIVALGK LLEPLQKSVL AAVVIANLKG MFMQVCDIPR LWRQNKIDAV
IWVFTCIASI ILGLDLGLLA GLMFGLLTVV LRVQFPSWNG LGSVPSTDIY KSTKSYKNIE
ELEGVKILRF SSPIFYGNVD GFKKCIKSTV GFDAIRVYNK RLKALRKIQK LIKKGQLRAT
KNGIIRDAGS SNNAFEPDED IEDPEDLDIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL
DCGAVSFLDV VGVRSLRMIV KEFHRIDVNV YFASLQDHVI EKLEKCGFFN DNIRKDIFFL
TVHDAVLHLQ NQVKSREVQD SILETITLMQ DCKDPLELME AELIEEELDV QDEAMRSLAS
//