ID M3Z3M0_MUSPF Unreviewed; 772 AA.
AC M3Z3M0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Semaphorin 3A {ECO:0000313|Ensembl:ENSMPUP00000018182.1};
GN Name=SEMA3A {ECO:0000313|Ensembl:ENSMPUP00000018182.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018182.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AEYP01005748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01005749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01005750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004739687.1; XM_004739630.2.
DR RefSeq; XP_004739688.1; XM_004739631.2.
DR RefSeq; XP_004739689.1; XM_004739632.1.
DR AlphaFoldDB; M3Z3M0; -.
DR STRING; 9669.ENSMPUP00000018182; -.
DR Ensembl; ENSMPUT00000018452.1; ENSMPUP00000018182.1; ENSMPUG00000018300.1.
DR GeneID; 101681742; -.
DR KEGG; mpuf:101681742; -.
DR CTD; 10371; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000158203; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; M3Z3M0; -.
DR OMA; TYLCHAV; -.
DR OrthoDB; 5342713at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl.
DR GO; GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11249; Sema_3A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042820; Sema3A_sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF23; SEMAPHORIN-3A; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..772
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004045724"
FT DOMAIN 31..514
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 590..665
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 729..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 89104 MW; 01914F03E5313566 CRC64;
MGWFARIVSL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF
LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV
LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP EDNIFKLEDS HFENGRGKSP YDPKLLTASL
LIDGELYSGT AADFMGRDFA IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED
DKVYFFFREN AIDGEHTGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR VFLGPYAHRD
GPNYQWVPFQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI TFARSHPAMY NPVFPINNRP
IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF IGTDVGTVLK VVSIPKETWH DLEEVLLEEM
TVFREPTTIS AMELSTKQQQ LYIGSTTGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS
SCSRYFPTAK RRTRRQDIRN GDPLTHCSDL QHHGNHHGHS LEERIIYGVE NSSTFLECSP
KSQRALVYWQ FQRRNEERKE EIRVDDHIIR TEQGLLLRSL QRKDSGNYLC HAVEHGFMQT
LLKVTLEVID TEHLEELLHK DDDGDGSKTK EISNSMTPSQ KVWYRDFMQL INHPNLNTMD
EFCEQVWKRD RKQRRQRPGH NQGNSNKWKH LQENKKGRNR RTHEFERAPR SV
//
