ID M3Z4V4_MUSPF Unreviewed; 295 AA.
AC M3Z4V4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=TAS2R5 {ECO:0000313|Ensembl:ENSMPUP00000018616.1,
GN ECO:0000313|RefSeq:XP_004741671.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018616.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004741671.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004741671.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5. {ECO:0000256|ARBA:ARBA00024847}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AEYP01008767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004741671.1; XM_004741614.3.
DR STRING; 9669.ENSMPUP00000018616; -.
DR Ensembl; ENSMPUT00000018888.1; ENSMPUP00000018616.1; ENSMPUG00000018736.1.
DR GeneID; 101692653; -.
DR KEGG; mpuf:101692653; -.
DR CTD; 54429; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR OMA; CRFLLQW; -.
DR OrthoDB; 5263908at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd13950; 7tm_TAS2R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF8; TASTE RECEPTOR TYPE 2 MEMBER 5; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004424};
KW Receptor {ECO:0000256|RuleBase:RU004424,
KW ECO:0000313|RefSeq:XP_004741671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004424};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 295 AA; 33707 MW; E50FAC55888AFECC CRC64;
MLSAALALLM VVAVAEFLIG LVGNGVLVVW SFGEWVRKFN GSSYNLIVLG LAVCRFLLQW
LIMMDLSLFP LFHSSHWLRY LSVFWILVSQ ASLWFAAFLS VFYCRKIMTL EHPVCMWLKQ
RAYCLSLWCL LGYFMISLLL VTLIGLKPYD PSQGNSSILY PFESWHYLYV LKLNAGSGLP
LMVFLVSSVM LIISLYRHHK KMKVYTAGRR DARAKAHITV LKSLGCFLIL HVVYILASPF
SIIYKSSANL LIIFISETVM AAYPSLHSVI LIMGNPRVKQ TCQRILWKMV CAWRS
//
