ID   M3Z946_NOMLE            Unreviewed;      1125 AA.
AC   M3Z946;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Anillin, actin binding protein {ECO:0000313|Ensembl:ENSNLEP00000023233.2};
GN   Name=ANLN {ECO:0000313|Ensembl:ENSNLEP00000023233.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000023233.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000023233.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000023233.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; ADFV01046503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3Z946; -.
DR   Ensembl; ENSNLET00000031598.2; ENSNLEP00000023233.2; ENSNLEG00000001988.3.
DR   eggNOG; KOG3640; Eukaryota.
DR   GeneTree; ENSGT00390000008749; -.
DR   Proteomes; UP000001073; Chromosome 17.
DR   CDD; cd01263; PH_anillin; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR012966; AHD.
DR   InterPro; IPR031970; Anillin_N.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037840; PH_Anillin.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21538:SF23; ANILLIN; 1.
DR   PANTHER; PTHR21538; ANILLIN/RHOTEKIN RTKN; 1.
DR   Pfam; PF08174; Anillin; 1.
DR   Pfam; PF16018; Anillin_N; 2.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          984..1108
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          562..589
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        28..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..653
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1125 AA;  124518 MW;  D14866C24376D5A5 CRC64;
     MRENLQRKMA ERPTAAPRSM THAKRARQPL SEASNQQPLS GGEEKSCTKP SPSKKRCSDN
     TEVEVSNLEN KQPVESTSAK SCSPSPVSPQ VQPQAADTVS DSVAVPASLL GMRRGLNARL
     EATATSSVKT RMQKLAEQRR RWDNDNMTDD IPESSLFSPM PSEEKAASPP KPPLSNASAT
     PVGRRGRLAN LAATICSWED DVNHSFAKQN SVQEQPGTAC LSKFSSASGA SARINSSSVK
     QEATFCSQRD CDASLNKAPS SSADDASLVN ASISSSVKAT SSPVKSTTSI TDAKSCERQN
     PELLPKTPIS PLKTGVSKPI VKSTLSQTVP SKGELNREIC LQSQSKDKST TPGGAGIKPF
     LERFGERCQE HSKESPARST PHRTPIITPN TKAIQERLFK QDTSSSTTHL AQQLKQERQK
     ELACLRGRFD KGSNIWSAEK GGNSKSKQLE TKQETHCQST PLKKHQGVSK PQSLPVTEKV
     TENQIPAKNS STEPTGFTEC EMTKSSPLKI TLFLEEDKSL KVTSDPKVEQ KIEVIREIEM
     SVDNDDDINS SKVINDLFSD VLEEGELDME KSQEEMDQAL AESSEEQEDA LNISSMSLLA
     PLAQTVGVVS PESLVSTPRL ELKDTSRSDE SPKPGKFQRT RVPRAESGDS LGSEDRDLLY
     SIDAYRSQRF KETERPSIKQ VIVRKEDVTS KLDEKNNGFP CQVNIKQKMQ ELNNEINMQQ
     TVIYQASQAL NCCVDEEHGK GSLEEAEAER LLLIATEKRT LLIDELNKLK SEGPQRKNKA
     SPVSQSEFMP SKGSVTLSEI RLPLKADFVC SMVQKPDAAN YYYLIILKAG AENMVATPLA
     STSNSLNGDA LTFTTTFTLF YLMLYLSRQD VSNDFEINIE VYSLVQKKDP SGLDKKKKTS
     KSKAITPKRL LTSITTVSRI FEKLIMASPG GLNAVRTSNF ALVGSYTLSL SSVGNTKFVL
     DKVPFLSSLE GHIYLKIKCQ VNSSVEERGF LTIFEDVSGF GAWHRRWCVL SGNCISYWTY
     PDDEKRKNPI GRINLANCTS RQIEPANREF CARRNTFELI TVRPQREDDR ETLVSQCRDT
     LCVTKNWLSA DTKEERDLWM QKLNQVLVDI RLWQPDACYK PIGKP
//