ID M3Z9B2_NOMLE Unreviewed; 672 AA.
AC M3Z9B2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Autophagy related 7 {ECO:0000313|Ensembl:ENSNLEP00000023299.2};
GN Name=ATG7 {ECO:0000313|Ensembl:ENSNLEP00000023299.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000023299.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000023299.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000023299.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01026106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01026115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Z9B2; -.
DR STRING; 61853.ENSNLEP00000023299; -.
DR Ensembl; ENSNLET00000031660.2; ENSNLEP00000023299.2; ENSNLEG00000027005.2.
DR eggNOG; KOG2337; Eukaryota.
DR GeneTree; ENSGT00390000017509; -.
DR HOGENOM; CLU_012998_0_0_1; -.
DR InParanoid; M3Z9B2; -.
DR OMA; RQIWDAI; -.
DR Proteomes; UP000001073; Chromosome 21.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0019778; F:Atg12 activating enzyme activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0000045; P:autophagosome assembly; IEA:Ensembl.
DR GO; GO:0071455; P:cellular response to hyperoxia; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0000423; P:mitophagy; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0031401; P:positive regulation of protein modification process; IEA:Ensembl.
DR CDD; cd01486; Apg7; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR InterPro; IPR032197; Atg7_N.
DR InterPro; IPR042522; Atg7_N_1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR Pfam; PF16420; ATG7_N; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 13..292
FT /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16420"
FT DOMAIN 308..568
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT COILED 413..440
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 672 AA; 74537 MW; 030CCE606D6C98B0 CRC64;
MAAATGNPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP
ARLTLEFSAF DMSAPTPARC CPAVGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGA
ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL
ECAYDNLCQT EGVTALPYFL IKYDENTVLV SLLNHYSDFF QGQRTKITIG VYDPCNLAQY
PGWPLRNFLV LAAHRWSSSF QSVEVLCFRD RTMQGARDVA HSIIFEVKLP EMAFSPLAES
SVDLNLKLMC WRLVPTLDLD RVVSVKCLLL GAGTLGCNVA RTLMGWGVRH ITFVDNAKIS
YSNPVRQPLY EFEDCLGGGK PKALAAADRL QKIFPGVNAR GFNMSIPMPG HPVNFSSVTL
EQARRDVEQL EQLIESHDVI FLLMDTRESR WLPAVIAASK RKLVINAALG FDTFVVMRHG
LKKPKQQGAG DLCPNHPVAS ADLLGSSLFA NIPGYKLGCY FCNDVVAPGD STRDRTLDQQ
CTVSRPGLAM IAGALAVELM VSVLQHPEGG YAIASSSDDR MNEPPTSLGL VPHQIRGFLS
RFDNVLPVSL AFDKCTACSS KVLDQYEREG FHFLAKVFNS SHSFLEDLTG LTLLHQETQA
AEIWDMSDDE TI
//
