ID M3ZAD7_NOMLE Unreviewed; 1445 AA.
AC M3ZAD7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Rho GTPase activating protein 31 {ECO:0000313|Ensembl:ENSNLEP00000023674.2};
GN Name=ARHGAP31 {ECO:0000313|Ensembl:ENSNLEP00000023674.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000023674.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000023674.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000023674.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01006427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01006428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01006429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01006430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000032050.2; ENSNLEP00000023674.2; ENSNLEG00000004857.3.
DR eggNOG; KOG1449; Eukaryota.
DR GeneTree; ENSGT00940000159458; -.
DR Proteomes; UP000001073; Chromosome 21.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF3; RHO GTPASE-ACTIVATING PROTEIN 31; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 17..214
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 382..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..792
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 157164 MW; 17D2333B934F97E2 CRC64;
YFAQGYKSSL VSKSALSTID CMVAGYRTVR CVPHVLKSCA EFIETHGIVD GIYRLSGVTS
NIQRLRQEFG SDQCPDLTRE VYLQDIHCVG SLCKLYFREL PNPLLTYELY EKFTEAVSHC
PEEGQLARIQ NVIQELPPSH YRTLEYLIRH LAHIASFSSK TNMHARNLAL VWAPNLLRSK
EIEATGCNGD AAFLAVRVQQ VVIEFILNHV DQIFNNGAPG SLENDENRPI MKSLTLPALS
LPMKLVSLEE AQARSLATNH PARKERRENS LPEIVPPMGT LFHTVLELPD NKRKLSSKSK
KWKSIFNLGR SGSDSKSKLS RNGSVFVRGQ RLSVEKATIR PAKSMDSLCS VPVEGKETKG
NFNRTVTTGG FFIPATKMHS TGTGSSCDLT KQEGEWGQEG MPPGAEGSFD VSSDRSHLQG
AQARPPPEQL KVFRPIEDPE GEQTAPKLLG MFYTSNDSPS KSVFTSSLFQ MEPSPRHQRK
ALNISEPFAV SVPLRVSAVI STNSTPCRTP PKELQSLSSL EEFSFHGSES GGWPEEEKPL
GAETSAASVP KKAGLEDAKP VPEAPGTVEC SKGLSQEPGT HLEEKKTPEI SLSSQHSNEL
EKRPNPEKVV EEGREAGEME SSTLQESPRA TAKAVLLHEM DEDDLVNALI WPEIQQELKI
VESEEELSSL PPPALKTSPI QPILESSLGP FIPPEPPGSL PCGSFPAPVS APLEVWTRDP
ANQSTQGAST AASREKPVPE QGLHPDLASL APLEIVPFEK ASPQATVEVG GPGNLSPPLP
PAPPPPTPLE ESPPVLLSKG SPEREDSSRK LRTDLYIDQL KSQDSPEISS LCQGEEATPR
HSDKQNSKNA ASEGKGCGFP SPTREVEIVS REEEDVTHSV QEPSDCDEDD TVTDIAQHGL
EMVEPWEEPQ WVTSPLHSPT LKDAHEAQVQ GLHGHQLEKR LSHRPSLRQS HSLDSKPTVK
SQWTLEVPSS SSCANLETQR NSDPLQPQAP RREITGWDEK ALSSFREFSG LKGAEAPPNQ
KGPSGVQPKP AETSPISLAE GKELGTHLGH SSPQMRQGGV PGPESSKESS PSVQDSPSPG
EHPAKLQLKS TDCGPPKGKN RPSSLNLDPA IPIADLFWFE NVASFSSPGM QVSEPGDPKV
TWMTSSYCKA DPWSIYSQDP QDPQDLDIVA HALTGRRNSA PVSVSAVRTS FMVKMCQARA
VPVIPPKIQY TQIPQPLPSQ SSGENGVQPL ERSQEEPSST SGTTQKPAKD DSPSSLESPK
EEKPKQDPGA IKSSPVDATA PCMCEGPTLS PEPGSSNLLS TQDATVQCRK RMSETEPSGD
NLLSSKLERP SGGSKPFHRS RPGRPQSLIL FSPPFPIMDH LPPSSTVTDS KVLLSPIRSP
TQTVSPGLLC GELAENTWVT PEGVTLRNKM TIPKNGQRLE TSTSCFYQPQ RRSVILDGRS
GRQIE
//
