ID M3ZBC8_NOMLE Unreviewed; 707 AA.
AC M3ZBC8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM2 {ECO:0000313|Ensembl:ENSNLEP00000024015.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024015.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024015.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024015.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR EMBL; ADFV01163651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01163660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3ZBC8; -.
DR Ensembl; ENSNLET00000032381.2; ENSNLEP00000024015.2; ENSNLEG00000015219.3.
DR GeneTree; ENSGT00940000159034; -.
DR HOGENOM; CLU_011310_1_1_1; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF22; METAL TRANSPORTER CNNM2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 109..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT DOMAIN 105..285
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 372..438
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 707 AA; 78817 MW; 96FCEF61F0AA4091 CRC64;
LQCGGIRTSD IIILPHIILN RRTSGIIEIE IKPLRKMEKS KSYYLCTSLS TPALGAGGSG
SAGGAVGGKG GSGVAGLPPP PWAETTWIYH DGEDTKMIVG EEKKFLLPFW LQVIFISLLL
CLSGMFSGLN LGLMALDPME LRIVQNCGTE KEKNYAKRIE PVRRQGNYLL CSLLLGNVLV
NTTLTILLDD IAGSGLVAVV VSTIGIVIFG EIVPQAICSR HGLAVGANTI FLTKFFMMMT
FPASYPVSKL LDCVLGQEIG TVYNREKLLE MLRVTDPYND LVKEELNIIQ GALELRTKTV
EDVMTPLRDC FMITGEAILD FNTMSEIMES GYTRIPVFEG ERSNIVDLLF VKDLAFVDPD
DCTPLKTITK FYNHPLHFVF NDTKLDAMLE EFKKGKSHLA IVQRVNNEGE GDPFYEVLGI
VTLEDVIEEI IKSEILDETD LYTDNRTKKK VAHRERKQDF SAFKQTDSEM KVKISPQLLL
AMHRFLATEV EAFSPSQMSE KILLRLLKHP NVIQELKYDE KNKKAPEYYL YQRNKPVDYF
VLILQGKVEV EAGKEGMKFE ASAFSYYGVM ALTASPGENK SPPRPCGLNH SDSLSRSDRI
DAVTPTLGSS NNQLNSSLLQ VYIPDYSVRA LSDLQFVKIS RQQYQNALMA SRMDKTPQSS
DSENTKIELT LTELHDGLPD ETANLLNEQN CVTHSKANHS LHNEGAI
//