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Database: UniProt
Entry: M3ZBC8_NOMLE
LinkDB: M3ZBC8_NOMLE
Original site: M3ZBC8_NOMLE 
ID   M3ZBC8_NOMLE            Unreviewed;       707 AA.
AC   M3ZBC8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN   Name=CNNM2 {ECO:0000313|Ensembl:ENSNLEP00000024015.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024015.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000024015.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000024015.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC       ECO:0000256|RuleBase:RU369091}.
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DR   EMBL; ADFV01163651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01163660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3ZBC8; -.
DR   Ensembl; ENSNLET00000032381.2; ENSNLEP00000024015.2; ENSNLEG00000015219.3.
DR   GeneTree; ENSGT00940000159034; -.
DR   HOGENOM; CLU_011310_1_1_1; -.
DR   Proteomes; UP000001073; Chromosome 3.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF22; METAL TRANSPORTER CNNM2; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        109..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        167..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369091"
FT   DOMAIN          105..285
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          372..438
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   707 AA;  78817 MW;  96FCEF61F0AA4091 CRC64;
     LQCGGIRTSD IIILPHIILN RRTSGIIEIE IKPLRKMEKS KSYYLCTSLS TPALGAGGSG
     SAGGAVGGKG GSGVAGLPPP PWAETTWIYH DGEDTKMIVG EEKKFLLPFW LQVIFISLLL
     CLSGMFSGLN LGLMALDPME LRIVQNCGTE KEKNYAKRIE PVRRQGNYLL CSLLLGNVLV
     NTTLTILLDD IAGSGLVAVV VSTIGIVIFG EIVPQAICSR HGLAVGANTI FLTKFFMMMT
     FPASYPVSKL LDCVLGQEIG TVYNREKLLE MLRVTDPYND LVKEELNIIQ GALELRTKTV
     EDVMTPLRDC FMITGEAILD FNTMSEIMES GYTRIPVFEG ERSNIVDLLF VKDLAFVDPD
     DCTPLKTITK FYNHPLHFVF NDTKLDAMLE EFKKGKSHLA IVQRVNNEGE GDPFYEVLGI
     VTLEDVIEEI IKSEILDETD LYTDNRTKKK VAHRERKQDF SAFKQTDSEM KVKISPQLLL
     AMHRFLATEV EAFSPSQMSE KILLRLLKHP NVIQELKYDE KNKKAPEYYL YQRNKPVDYF
     VLILQGKVEV EAGKEGMKFE ASAFSYYGVM ALTASPGENK SPPRPCGLNH SDSLSRSDRI
     DAVTPTLGSS NNQLNSSLLQ VYIPDYSVRA LSDLQFVKIS RQQYQNALMA SRMDKTPQSS
     DSENTKIELT LTELHDGLPD ETANLLNEQN CVTHSKANHS LHNEGAI
//
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