ID M3ZCG1_NOMLE Unreviewed; 962 AA.
AC M3ZCG1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|Ensembl:ENSNLEP00000024398.2};
GN Name=SLC12A6 {ECO:0000313|Ensembl:ENSNLEP00000024398.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024398.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024398.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024398.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; ADFV01073629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01073637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3ZCG1; -.
DR Ensembl; ENSNLET00000032761.2; ENSNLEP00000024398.2; ENSNLEG00000010859.3.
DR eggNOG; KOG2082; Eukaryota.
DR GeneTree; ENSGT00940000160238; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..175
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 294..572
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 586..704
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 718..962
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 962 AA; 106965 MW; C1B596691FA1F324 CRC64;
MDTRPKVSSL LNRMANYTNL TQGAKEHEEA ENITEGKKKP TKTMLTAISM SAIATNGVVP
AGGSYFMISR ALGPEFGGAV GLCFYLGTTF AAAMYILGAI EIFLVYIVPR AAIFRSDDAL
KESAAMLNNM RVYGTAFLVL MVLVVFIGVR YVNKFASLFL ACVIVSILAI YAGAIKSSFA
PPHFPVCMLG NRTLSSRHID VCSKTKEINN MTVPSKLWGF FCNSSQFFNA TCDEYFVHNN
VTSIQGIPGL ASGIITENLW SNYLPKGEII EKPSAKSSDV LGSLNHEYVL VDITTSFTLL
VGIFFPSVTG IMAGSNRSGD LKDAQKSIPI GTILAILTTS FVYLSNVVLF GACIEGVVLR
DKFGDAVKGN LVVGTLSWPS PWVIVIGSFF STCGAGLQSL TGAPRLLQAI AKDNIIPFLR
VFGHSKANGE PTWALLLTAA IAELGILIAS LDLVAPILSM FFLMCYLFVN LACALQTLLR
TPNWRPRFRY YHWALSFMGM SICLALMFIS SWYYAIVAMV IAGMIYKYIE YQGAEKEWGD
GIRGLSLSAA RFALLRLEEG PPHTKNWRPQ LLVLLKLDED LHVKHPRLLT FASQLKAGKG
LTIVGSVIVG NFLENYGEAL AAEQTIKHLM EAEKVKGFCQ LVVAAKLREG ISHLIQSCGL
GGMKHNTVVM GWPNGWRQSE DARAWKTFIG TVRVTTAAHL ALLVAKNISF FPSNVEQFSE
GNIDVWWIVH DGGMLMLLPF LLKQHKVWRK CSIRIFTVAQ LEDNSIQMKK DLATFLYHLR
IEAEVEVVEM HDSDISAYTY ERTLMMEQRS QMLRHMRLSK TERDREAQLV KDRNSMLRLT
SIGSDEDEET ETYQEKVHMT WTKDKYMASR GQKAKSMEGF QDLLNMRPDQ SNVRRMHTAV
KLNEVIVNKS HEAKLVLLNM PGPPRNPEGD ENYMEFLEVL TEGLERVLLV RGGGSEVITI
YS
//
