ID M3ZD87_XIPMA Unreviewed; 355 AA.
AC M3ZD87;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Clavesin-2 {ECO:0000256|ARBA:ARBA00013642};
DE AltName: Full=Retinaldehyde-binding protein 1-like 2 {ECO:0000256|ARBA:ARBA00031836};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000179.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000000179.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000179.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR AlphaFoldDB; M3ZD87; -.
DR STRING; 8083.ENSXMAP00000000179; -.
DR Ensembl; ENSXMAT00000000179.2; ENSXMAP00000000179.2; ENSXMAG00000000183.2.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000157632; -.
DR HOGENOM; CLU_046597_4_2_1; -.
DR InParanoid; M3ZD87; -.
DR OMA; QNERLCD; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR GO; GO:0097205; P:renal filtration; IEA:Ensembl.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.20.5.1200; Alpha-tocopherol transfer; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.8.20; N-terminal domain of phosphatidylinositol transfer protein sec14p; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR PANTHER; PTHR10174; ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED; 1.
DR PANTHER; PTHR10174:SF73; CLAVESIN-2; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR PRINTS; PR00180; CRETINALDHBP.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 118..279
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 315..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 40928 MW; BC54E773C7F9DA14 CRC64;
LGETGMLPSS VKPPTEGQLL QTMTHLQAGL SPETLEKAKV ELKENPETLH QDIQEVRDMI
ITRPDIGFLR TDDAFILRFL RARKFNHFEA FRLLAQYFEY RQQNLDMFKN LKATDPGIKQ
ALKDGFPGVL SNLDKYGRKI LVLFAANWDQ SRYTFVDILR AILLSLESMI EDPELQVNGF
ILIIDWSNFT FKQASKLTPS MLRLAIEGLQ DSFPARFGGI HFVNQPWYIH ALYTVIRPFL
KDKTRKRIFM HGNNLNSLHQ LIHPEILPSE LGGMMPPYDM GTWARTLLDH AYDEETDYCP
ESYTLSVQDL ERDLEKNMSP KTMKRSQSVV EPGVLKRPDK VKSEEDNLQP LLSLD
//
