ID M3ZEK0_XIPMA Unreviewed; 1245 AA.
AC M3ZEK0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000642.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000000642.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000642.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M3ZEK0; -.
DR STRING; 8083.ENSXMAP00000000642; -.
DR Ensembl; ENSXMAT00000000644.2; ENSXMAP00000000642.2; ENSXMAG00000000634.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000164854; -.
DR HOGENOM; CLU_004732_0_0_1; -.
DR InParanoid; M3ZEK0; -.
DR OMA; HECVEHP; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF421; PROTEIN JAGGED-2; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1245
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017398587"
FT TRANSMEM 1082..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..229
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 230..263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 296..334
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 336..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 374..410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 412..448
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..485
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 487..523
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 525..561
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 590..627
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 629..665
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 667..703
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 705..741
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 744..779
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 819..855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1115..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 187..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 200..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 253..262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 324..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 400..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 438..447
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 454..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 475..484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 513..522
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 551..560
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 617..626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 655..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 693..702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 731..740
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 769..778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 807..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 845..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1245 AA; 136736 MW; C8BE2BFFBF4B2D51 CRC64;
MWNNPGKAHR FFILCFLLTV CTEVCQSSGY FELQLISVEN PRGQLLNGDC CDSEGRQADG
NCGLDECDTY FRVCLKEYQQ EVKIGGPCTY GSEITKVIGG NTFQFRGSQK GSHDTGKIVI
PFQFSWPQDY TLIVEAWDKD NGTRGSDDEL LIERSIYKGK INPGEGKQSV EHKSFIATIK
YTMRVRCDEH YYGMRCNNVC RPRDDYFGHY VCDHFGKRHC IEGWEGEDCK TAICKQGCSS
LHGTCSTPGE CKCNYGWDGP LCDRCLPYPG CVHGTCTEPW QCTCEKNWGG LLCDKDLNYC
GTNQPCKNGG TCMNTEPDEY NCACLDGYSG KNCEIAEHAC LSNPCANGGT CHEVPSGFEC
HCPAGWSGPT CAEDTDECAS APCAHGGTCI DMENGYECLC PVQWTGKTCQ IDVNECGGKP
CLNAYYCKNM IGGYHCACFP GWVGHNCHIN MNSCHGQCQN GGTCKNTARG YQCVCLPGFV
GRHCEAQRNH CPSSPCRNGG RCHAHLEGFV CDCPPGFTGT TCEVQNDPCN PNPCQRKSQC
NSLAGDFYCS CPEDYEGKTC SELKDHCKTH QCEVIDSCTV AIATNDTQQQ VWHISSNVCG
PHGRCISLPA GNFSCSCYPG FTGTYCHENI NDCVSYPCKN GGTCIDGISS FECVCPGGWE
GDLCDVDVNE CSSNPCQNRG QCVDLFHDFS CNCVDNWKGK NCHLRESQCD SNTCRNGGTC
YDRGDSFLCR CPSGWAGNTC NTAKNSTCDS DPCENGGTCV GGEPFTCICK AGWEGPTCAQ
NIDDCNPHPC YNSGICVDGV NWFRCECASG FAGPDCRINI NECQSSPCAE GSTCIDEISA
YRCVCPPGQA GPQCQQFMGL GKSCRHAGLQ YPHSSHWEED CNACQCVNGE VHCSKVKCGR
RPCVLPNAVL PSVTSHQPCP GGLECVKHPL LTCLSPPCHQ WGVCSTPDPP TPTQHTQCEP
HSGYLDNRCA HITLIFNRDK VPQGTAVENI CSELRYLPVT RMLAVDRELI ILCDLSYYTR
NAVEVAMSFE MDGQLKDSDC GYIQNAAAAI TSALSKYHNS TILQAVVEAR VEMQAECRAE
GYLVPVLGVV FSLLWVFCLV VCVWWTRKRK KERERSALSE DTTVNNQLEP LRSNTPKDNR
DKDIQYECKK LIGPSDRTCD EPEEEEQQLE EDEEMVLGLG DKCLSHKCPI VGAQDRSTNI
KAEVMCTILS GPVKAPHRTA YSPKDNRCKN LNAAKFSEDI TDLCV
//