ID   M3ZER1_XIPMA            Unreviewed;      1025 AA.
AC   M3ZER1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 {ECO:0000313|Ensembl:ENSXMAP00000000703.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000703.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000000703.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000703.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; M3ZER1; -.
DR   Ensembl; ENSXMAT00000000705.2; ENSXMAP00000000703.2; ENSXMAG00000000688.2.
DR   eggNOG; ENOG502QRQB; Eukaryota.
DR   GeneTree; ENSGT00390000015458; -.
DR   HOGENOM; CLU_011989_0_0_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   InterPro; IPR017216; HPS3.
DR   InterPro; IPR029438; HPS3_C.
DR   InterPro; IPR029437; HPS3_N.
DR   PANTHER; PTHR28633; HERMANSKY-PUDLAK SYNDROME 3 PROTEIN; 1.
DR   PANTHER; PTHR28633:SF1; HERMANSKY-PUDLAK SYNDROME 3 PROTEIN; 1.
DR   Pfam; PF14763; HPS3_C; 1.
DR   Pfam; PF14761; HPS3_N; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   DOMAIN          3..167
FT                   /note="BLOC-2 complex member HPS3 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14761"
FT   DOMAIN          194..487
FT                   /note="BLOC-2 complex member HPS3 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14761"
FT   DOMAIN          506..1022
FT                   /note="BLOC-2 complex member HPS3 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14763"
FT   REGION          171..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1025 AA;  113770 MW;  85E3B6EA123E75F2 CRC64;
     MVHVYNCHPF TSQQIVQVEQ EPGLVCCGGG ALFVVTTGGC KVEVYNLETE GCPLICRFAS
     MGTVRRIRHS SIGDYLVTIE EKNSATYLRV YTNWRHQAEE KSRVGVRLLG HLLRGASVWG
     GVQMEIIEIP LSEHPVSLAC CALTGDLLVG CENTLVLFTL RRHTQQNLQN QQNLQSSWSN
     SEQSCSQSPG RTSQNQELSV LDFERSVILH LSKITPKQVA LCGGYVAVQA ELEVLVLKLE
     ATAEPTGVEE HSDSFKSEDY PEEQSDFLLV PKHQELLGDG ARTCDVPVSV EQTGLEDRRH
     YTLSYLLFRR FTPEFFQGCS VEEIQLHSLQ LHPMTTSKQS ASVDEPACMF CFFSLPTAGY
     LYSLRGGVEL LSTYQYPEKA LQAVLTDHLL HVITRNALQS FTVRCAALAA RVEDPYIDTT
     MKACPPCSLE VCALRMQLFI GLRSLCVFGR HVVLLSTADT EAPEETERHT QRRGLSRRWA
     ISSPKETSPV GHGWNLYVVD TVPPITLHQE MVEYSQRYAE TNPQGLSLRH LLSEAHLLLR
     SSLLESSEQR QASEGVRKMA AQTYGEELEE AFRQNSAQLG DSFSRGSQKD CHLALPYYRM
     SGLSVTEVMS RNRPLPGSPH SYGPGFLFYL KNYLLEETDQ ILGQEDADEV TRIFSQSEPS
     MLVSACASPC MMNVDPAATL QILQRLEETA GVSVPLTITM ATMMLRLGNM AQYTELMERH
     AEMLLVYGFI EEPRLLLHTA GGGGGGKHPQ VRPTALAAQL ADSQPGLLVA AMVALHENNK
     VQLEPADHVF KELGCESSLQ VDFWEAMLMA SSQDAVIQEL VFRLASVYID RLTAGESPTK
     HKSLKSVDDL ISCCSHYGAL YPWLTVLNPA QTSSYQHQEA LHKLQSLLCG PSLSIGNVAP
     LLESLSEETL WGFSLHLLCA TRRGHYGSSI ERLLDRCPQA IIAYANHQLQ DKHMALWWQK
     LLPELCNRTR AAADNGFLLG ALTETLVVVA METSPAEFLE LLPDDGSASF FLPHLLTCGQ
     KHLPA
//