ID M3ZFI3_XIPMA Unreviewed; 2942 AA.
AC M3ZFI3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Neural-cadherin-like {ECO:0000313|Ensembl:ENSXMAP00000000975.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000975.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000000975.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000975.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8083.ENSXMAP00000000975; -.
DR Ensembl; ENSXMAT00000000978.2; ENSXMAP00000000975.2; ENSXMAG00000000960.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164020; -.
DR HOGENOM; CLU_000347_1_0_1; -.
DR InParanoid; M3ZFI3; -.
DR OMA; EPWCAKV; -.
DR OrthoDB; 2907364at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 17.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 17.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 12.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 18.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 17.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 7.
DR PROSITE; PS50268; CADHERIN_2; 16.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2942
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017446638"
FT TRANSMEM 2677..2697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 266..365
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 368..466
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 467..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 577..669
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 670..776
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 780..885
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 886..985
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 986..1097
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1098..1212
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1213..1314
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1315..1421
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1431..1541
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1542..1649
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1659..1755
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1755..1887
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2118..2157
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2158..2359
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2362..2401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2404..2581
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2624..2660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 239..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2788..2848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2869..2921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2796..2824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2876..2903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2147..2156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2391..2400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2628..2638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2650..2659
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2942 AA; 323514 MW; 225D81A3BBA41282 CRC64;
MIWVTFLPFL MPCVAANRTS DLVPFFHGHV FENSSPGSRV NGLSVPLKRL NSRRLCGTAQ
PCSAAAHYKL LGDGSEDFRV FAHHKRGHVL LKTTQTLDRE ERAEYALSLG LCCGQWAEGE
DASELVASIK VDVLDTNDHQ PVFPSANMKL DLDDATALRA AICSLSARDG DSGKNAELIY
FAEPKNGSFY AVPKTGDILL VDSILGLEEP IKFQVFARDR GWPPRTSQGV SVEINPRQWP
AARSATPGPR QQVEAQARKS RSVTEEETPV LISVSEDAGI GSVVVNLNPV RFQSAAFELV
EPELESSPVS VNRDGGDVVI MRRLDRETEP LVEITVRVQD KRGLEWYLVR VELTVTDVND
NIPEWSMVPA PYLAVVSPDA TAGSLVYKLI AQDGDEGLNG EVEYFLSDGG DGRFEVDRKS
GQIRTTGLPL QRDREYLLTV VAADGLGSRS APAIISVVAG ARPPQFTNSS FVIAIPENTP
EGQPFLVTPA VSFQKKPISY SLLINPSSLF SISADTGEIS LTRTIDYESD QHRYLLLVRA
SEGQDSMSSA AEVRVVIVDE NDCVPEFLQS IYSKDGVPEM VTTATSLLQV SANDCDSGPN
ADLTYYTLSP DFIISPHGTI FPAGPLDYER PNHLYEFVVM AIDKGDVPRT GTTTVRIRMA
NVNDEAPEFS QHIYRTFVSE DAGPNTLVAT VLAKDPDGDG ITYKITTGND EGNFVIDSQK
GLIRLRSSPP PRLQGVEYVL NVTATDDNAS GGPQALASTA QVIVGVDDVN NNKPVFEQCQ
QYRESTSVLE NQPAGSFVLQ VHAVDADEGS NGRVTYGFMH KDSTVPAFSI HPDTGVIVTA
RKFDRERQRE YAVTVTATDQ AADPLIGICQ LNILILDQND NSPKFENLRY EYFLREDTMI
GTSFLRVAAH DDDFGSNAAV TYTMSGEQPE YLRVNPLTGW VYVNQPISQR TYITREIVAT
DGGNKSSSVE LAVTITNVKN QPPQWEKDTY SVVIPENTVR DTPVVTIKAT SPLGDPRVTY
NLEDGMVPET NMPVRFYLTP NREDGSASIL VAEPLDYETI RNFILRVRAQ NVAAVPLAAF
TTVYVNVTDV NDNVPFFTSS IYEASVTEGA ESGTLIFQVS ANDLDLGLNG KISYSLLEDR
SGDHKYFRID SELGFIYSQA VFDRETKSSY LLEVQSVDGW ESSRPGKHGQ PNSDTAYVRV
FISDVNDNKP LFAQASYEVD VDEDADVGFA ILTVSANDGD EGGNAKLRYQ ITSGNTGGVF
DVEPEVGTIF IAQPLDYEQN KRYKLHVLAS DGKWEDYTTV TVNVVNKNDE SPVFTVNEYY
GSVTEELDGS PVFVLQVTAS DPDKDADQEA LRYSLHGQGA ESEFIIDEVT GKIYAQRTLD
REERAVWRFV VLATDEGGEG LTGFTDIIIN VWDINDNAPV FPCALSCHGD VAENSDIGTS
VMEMTATDLD DSAVGQNAVL SYRIVGILDA TNAKLGGVPT ISEMFTINPT TGTITVALSG
LDREQVESYL LLIEARDGGG MTGTGTATVQ ITDVNDHAPR FIDHSCQARI SENSEPNAQV
LELAAEDRDT GENAQLTFSV VAGDQEQKFY MVSHKQEQRG VLRLKKRLDY ERHSEQKFNL
TLKVEDLDFS SFLHCVVEVE DYNDHTPVFI PHFLSLAPLP EDVSVGTSVA RLVASDSDSG
QNREITYSLS KDSDPEGLFT IDQSGLLSVA RPLDREKTAQ YHLVVIATDH GMPALTGSAT
VLLPLLDVND NGPEFEAAYS PVVFENVAGP QVVRLNQTSA LLRAVDRDSP ENGPPFHFTV
PPEYRYSNDF YLQDNLNGTS TLTALRTFDR ERQKEFLLPI VMSDSGRPAK TVTSTLTVTI
GDQNDHAHVA GEKQISINSH RGRMPTTVLG KVYAPDPDDW DNKTYVFEGH MPSYFILNKR
TGFLIIKENT LPGTYQFQVR VSDGIWPDAV STVTVYVREL RDEAIFNSAS LRLADITAKE
FMELRGKQRS RYELLVDFLS EMLSVPPGEV NIFSLLDVKE RMLDVRFAVS AGPSFLQPEK
MHGYLAAHKQ KLQSFLQVSV SQVRVDECPG TECAGSGGCT SVLEVRDAPT VVDCGTMSLV
SVMVESKAVC SCPGREQSHQ PCASYPRNPC FNGGLCVDTQ HGYRCQCPAQ FEGPECQQNK
HSFHGNGYAW FPPMMPCFES HVSLEFITDV ADGLLLYSGP LAQLQAWDHE DFMAIELIDG
TPTLKINHGS GTLVLQLPGN INVADRRWHR LDVRSNSKEV RFTLDRCSGA AVMEMEGLGS
WLTTEDHSSC EVTGVTPNTD RHLNTSQVLQ LGGVNEDIPY IYPQLQHKHF TGCIRNLIVD
SKLYDLGSPA DWQSSSPGCL TTDSSCVNMG FPACGHRGRC HGEWGSFSCQ CVAGYTGQQC
EEVAPEYSFD GHSHLHYQLA SALPARRTWI QVLVRTRKHS SIIVSLVSRD QSEYLRLEVF
QGLLCTFYNL GDGDYNLTLP SYRLDNGEWH DVSLDRHDNE MTLRLDGGGG KREVTGLQSR
SREIIIDPTA VMLGNSLPSE SNKSFQGCIR DLRLNGRYMP LDSQPRDGVS QVSVQGLSVG
CSSDSCKKYH CKAPFTCVDL WRVHECRCPP GHMIRVNGTK KSCVYTLCAT RPCHRGTCVA
QSPSKFTCHC PEGYRGRHCE TTLAVYREDV GLSFSSLFAI CICFMALLVL LLGIFLYTRW
RSYKGLKEGV YHVSAHHDGW EDIRENVLNY DEEGGGEEDQ NAYDMAELQK SLQPSPAQSV
QYCRSRALHH PPPAHHLHHH LLHQAPPVLA SAPPLDPLSR TSSSTTLPPS AASTSSTATT
TASLRRDVPP ARPPAQGQAR PSQLARRSLS FSSQDLARYL CEIIRDADQH PDTGPFDSLQ
VFSTEGGGSP AGSLSSFSSA GLDGGSTGEG AGEARREETL GEWGPRFEKL RALYERAEAS
DL
//
