ID M3ZH10_XIPMA Unreviewed; 1105 AA.
AC M3ZH10;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 3 {ECO:0000313|Ensembl:ENSXMAP00000001502.2};
GN Name=SRGAP3 {ECO:0000313|Ensembl:ENSXMAP00000001502.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001502.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001502.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001502.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M3ZH10; -.
DR STRING; 8083.ENSXMAP00000001502; -.
DR Ensembl; ENSXMAT00000001505.2; ENSXMAP00000001502.2; ENSXMAG00000001436.2.
DR eggNOG; KOG3565; Eukaryota.
DR GeneTree; ENSGT00950000182824; -.
DR HOGENOM; CLU_005715_0_0_1; -.
DR InParanoid; M3ZH10; -.
DR OMA; MEAFIKX; -.
DR OrthoDB; 2904755at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF8; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..314
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 506..694
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 742..801
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 205..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 810..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 125122 MW; 256DFD20019CEE5D CRC64;
MSSTKIKKDK EIIAEYETQV KEIRNQLVEQ FKCLEQQSES RIQLLQDLQE FFRRKAEIEL
EYSRSLEKLA ERFSSKIRSS REHQQFKKDQ HLLSSVNCWY LLLNQTRRES RDHATLSDIY
TNNVIVRLAQ ISEDIIRLFK KSKEIGIQMH EELVKVTNEL YTVMKTYHMY HTESISAETK
LKDAEKQEEK QFSKSGDLNV NLLRHEDRQP RRSSARKIEK MKEKRQAKYS ENKLKCTKAR
NDYLLNLAAT NAVVAKYYIH DVSDMIDCCD LGYHASLART FRTYLSAEYN LETSRHEGLD
IIENAVDNLD SRSDKHKIMD MHNQVFCPPM RFEYLPHMGD EVCQVSAQQP VQTDLLMRYH
QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD AFQHSRSTES IKSVASESYM
NKLNVAKRRS NQQETETFYF SKFKEYLNGS NLIIKLQAKH DLLKQTLGEG ERAECGTTRP
PTLPPKPQKM RKPRPRSMFN HKLFNGNMET FIKDSGQPIP LVVESCVRYI NLYGLQQQGI
FRVPGSQVEV NDIKNSFERG EDPLIDDQND HDINSVAGVL KLYFRGLENP LFPKERFLDF
ISTIKLESEA ERAHHIQQIV VTLPRTVIIV MRYLFAFLNH LSQYSDENMM DPYNLAICFG
PTLMPIPDGQ DPVACQAHVN EVIKTIIINH EVIFPNQREL DGPVYEKCMT GGEEYCDSPH
SEPGTIDEVD NGTEPHTSDE EVEQIEAIAK FDYTGRSPRE LSFKKGASLL LYHRASEDWW
EGRHNGVDGL IPHQYIVVQD LDDAFSDNLS QKADSEASSG PLLEEKGSSK NDIPSPCEQS
ADYNFGGVMG RVRLRSDGAA VPRRRSGGAE THSPTRVPDT PPRAAACPSS PHKISISKAR
IESPEKRRLG TFGSAGSINY PDRKAYPEGH PLRPVPGATR HSSLGDHKTL ETEALAEDIE
KTMSTALHEL RELERQNTVK QAPDVVLDTL EPMKNPASSE PGSPLHTIMI RDPDAAMRRS
SSSTSEMMTT FKPALSARLA GAQLRPPAMR PARSAPTQHR SSSSSSSGVG SPAVTPTEKL
FPSNSSASGS NVNVSGDAGD KTGSM
//
