UniProt: M3ZHP9

Database: UniProt
Entry: M3ZHP9_XIPMA

LinkDB:  M3ZHP9_XIPMA 
Original site:  M3ZHP9_XIPMA

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Ontology (4)   
   GO (4)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (7)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (10)   
   InterPro (7)   
   Pfam (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (25)   

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ID   M3ZHP9_XIPMA            Unreviewed;       329 AA.
AC   M3ZHP9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651};
DE            EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981};
DE            EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410};
DE   AltName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00033119};
DE   AltName: Full=Dithiolethione-inducible gene 1 protein {ECO:0000256|ARBA:ARBA00032255};
DE   AltName: Full=Leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00031851};
DE   AltName: Full=NAD(P)H-dependent alkenal/one oxidoreductase {ECO:0000256|ARBA:ARBA00032297};
GN   Name=PTGR1 {ECO:0000313|Ensembl:ENSXMAP00000001741.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001741.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000001741.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001741.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate +
CC         NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate +
CC         H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974,
CC         ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213;
CC         Evidence={ECO:0000256|ARBA:ARBA00023498};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin
CC         F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374,
CC         ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590;
CC         Evidence={ECO:0000256|ARBA:ARBA00023548};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-
CC         oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133408;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-
CC         oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:79072, ChEBI:CHEBI:133411;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-
CC         leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133346;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) +
CC         NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-
CC         (6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) +
CC         NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC   -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}.
CC   -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family.
CC       {ECO:0000256|ARBA:ARBA00010460}.
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DR   RefSeq; XP_005807314.1; XM_005807257.1.
DR   STRING; 8083.ENSXMAP00000001741; -.
DR   Ensembl; ENSXMAT00000001745.2; ENSXMAP00000001741.1; ENSXMAG00000001740.2.
DR   Ensembl; ENSXMAT00000041496.1; ENSXMAP00000020821.1; ENSXMAG00000001740.2.
DR   GeneID; 102216857; -.
DR   KEGG; xma:102216857; -.
DR   eggNOG; KOG1196; Eukaryota.
DR   GeneTree; ENSGT00940000154810; -.
DR   HOGENOM; CLU_026673_29_3_1; -.
DR   OMA; PIKNIHN; -.
DR   OrthoDB; 179761at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR   CDD; cd08294; leukotriene_B4_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR014190; PTGR1.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   DOMAIN          20..327
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   329 AA;  35778 MW;  FFE71C9B2D40B577 CRC64;
     MVQAKSWTLV KHFDGFPKDG DFQLKVEELP EPNDGEVLLE AVFLSVDPYM RPFSRFHMKE
     GDVMIGTQVA KVVQSKNPEF PVGSHVVSNS GWRSHSVSDG TDLTPIMADW PSDVSLSLAL
     GSIGMPGLTA LYGIEEVLGL QQNETLLVNA AAGAVGNVVG QIAKIKGCKV VGSAGSDAKV
     AYLKELGFDE AFNYKTVPSL EEALKNAAPE GYDCLFENVG GYFSTVALPQ MKTFGRIAVC
     GSISTYNDGT PQTGPYPHMT MIVKQLKMEG FTQNRWQHKN PESLKRMIGW LQEGKLKCRE
     HITEGFENMP AAFMGLLRGD NIGKAVVAV
//

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