ID M3ZIA5_XIPMA Unreviewed; 4072 AA.
AC M3ZIA5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSXMAP00000001947.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001947.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001947.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001947.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR STRING; 8083.ENSXMAP00000001947; -.
DR Ensembl; ENSXMAT00000001952.2; ENSXMAP00000001947.2; ENSXMAG00000001907.2.
DR eggNOG; KOG0891; Eukaryota.
DR GeneTree; ENSGT00940000155633; -.
DR HOGENOM; CLU_224534_0_0_1; -.
DR InParanoid; M3ZIA5; -.
DR OMA; PSPMCRE; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0071707; P:immunoglobulin heavy chain V-D-J recombination; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0033153; P:T cell receptor V(D)J recombination; IEA:Ensembl.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2846..3486
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3670..3997
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4040..4072
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2026..2051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2580..2617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2712..2739
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4072 AA; 461869 MW; AF9D506957BA4385 CRC64;
MAGVLSSQSV PASGIQGLLL KLHELLSDED SRSAALKCHD IIGDLGQECM LTATENELAL
QTSLLFSKDY GLLSFLRKSL PLEELRDTRV EILLFLEKFL DKVSPRVKGW EKTYDVCYVT
FNKKVAKCRT PVLELLIKVL QTTKASSVAA EFKIGDIFNR FYSELCQRSK LPDSVLGKIY
ELLGVLAEVH PSEMVNNSDK LYKVYLAELK EQMTSSTKEP KLLVVAGCLR GLTALMVNFA
KTMEEDPVTS KEIFQYALKS ITPQSIFLPA AGLRLFARHA SQFSGCLMDH YRALFETMCK
LCGHINGEMK KTSYSALEAF LKQVALLVAD NIEEHKSKLK FFMQKFCGII KTMESTHKEL
SIAIRGYGFF AAPCKKVCPQ DVDLMYTELI QRCKQMYLTE SDGEDDSFYQ LPSFLDSIAS
VLIHLDKIPE VYTPLLERLL VVQIDTFPQY SERMQFACSR SILKVFVAVA SKGPVLWSFI
SSVVHQGLIR VCSKPITLPE VSRAVYISSE SAEVRTGKWK VPASANYLPL YKGLLDCDQL
KDSGFLDGAF LSQNAALGSV SRLLYDELVK SILRIVEKLD LSVQKIATGE EVTAPDDAAH
VLPSSDPTAN LLPNKIKDFT AFINLVDFCS ELLLNTHVEY FQSWMYPLSH ELILHSIRNP
LVSGFYKLLS VGMKIAKRIK YYQVIFPLSA CFALFSKFGK EVCVRMKQYK DELLASCLTF
VLSLHHNIVA LDMKAYSPAL ETALRLGLSH IPLANAALDA LEDWSSRLPL DTMQPCYADI
LPLLDGYLKT TSSSDKDESN WEVMSSLSSR RDKGYSRVMT RLLKKSNQLS MEDVPLVTLR
LRVVKLLGHL GGKLNRNLVT VVSSEEIMKK FVAWDSEKRL SFAVPFTDMK PVIYLDPFLP
RVSELALSTS DRQTKVAACE LLHSLVVYMV GKSAQMVEGE NRLPPMYKLH KKLFPVLLRL
ACDVDQVTRQ LFEPLVMQLI HWFTNNKKFE SQDTVAVLEA ILDGVIDPTD STLRDFCGRC
IEEFVKWSIK QTTPKQQEKS PANMKSLFKR IYSLALHPNG FKRLGAGLAF NSIYRQFREE
NSLVEQFVFE VLVIFVESLA LAHSDERSMG TVQQCSSAID HLKRIIKHKA PSLNQHNAKR
RIPRGFPPDE KLCLSDLVVW LLEQCGRPQT ECRHKCMELL YEFIPLLPGK KSPPQWLEGM
LKDHGIDFLI SRFEGGGLLS QPTLRDLTGP FSVRATLQWM DLLLAVLDCY NTFIDLHIIK
PQHILSSKDK SSFLKATHFF LMELASRGLA AAESCFGRGE RMSHFSPREV DQYNYSKCTI
TVRLLEFASM ILVKGDQGFW KLLEQEVFCS VFFELTAAVV CEPSAVGFNM ADVEVMRNLP
EVCVPLLKAL MASPYCGRLE SSLRTKISRK SVEKLCEVDL YHSGSLSHHE QMEMVLSSCK
QIHKAGLLSS ILHSQDAAYG SSLGHKLLMT VYKGIAPGGD RKALPSLDVN TRRLADGLLQ
LTFSISQQSE QLVELLLNTI MLSVPISGGH SHNFLSFSHG EYFYSLFQAT INTELLKNLE
TAVPRLMKAS SENPSMVSVL LNGMLDHSFR ERSVRKTQGQ KLVEEILRRW MSLQSWWDGP
SSTSESKTAI LLLLSKLLQI DSSVCSDVDH KAFQQVFSTF TLLLVDMNLP LNLKSQALLV
LPFFTTLKGE PLAGLQRALD AVVASHFPMQ SDEFAKGSLH RNNYMDCIRK LLDALELSQS
PLLLRLMAGV LCRDGKHIME EQFQTCFQRI VLDSYLQLLS AVNEVIQQGD VPVSSMLQGL
TERVLLPLAS HCGTKALSDF FVMNVFDIIT FLQSRFTKSS EAAFEVQLLR KNGCYKMMEL
LYSRLPKDEV YSKESRINQA FCCLEKTEGN ELSKTLIKSC FEAFTENMAG ETQLLELRRG
YHCAAYNCAM AVISCSFSEP KFYQGFLFSE KPEKNQFILE NIIDVQRTYS FPIEIENYIN
QFLPGAVAVR VSTEAPVYLS SQSYMADSSL SEEMSQFDFS TGVQSFSFSS QNPQGHKRTA
ETEDRSPAPG GMVDLEMDEL NQHECMATMT ALIQHMQRSN ITPKIEQGTT PDELPPWMKF
LHGKLANPAT PLNIRLFISK LVINTEEVFR PYAKHWLGPL LQLVVSGSNG GVGIHFMVVD
IVVTVLSWIG LVTPKGNPRD EVLANRLLEF LMKHSFHPKR AVFRHNLEII RTLVECWKNC
LHVPYSLIYD RFCGTDPNSK DNSVGLQLLG IILANNLPAY DASCGIEYER YIQSLGNNLS
FTRYKDVYSA AAEIIGLGLK SMTETGDQEL FNLAATKITD LKKKDLDDKF IICLNKVTKH
FPPFMDRFVN HVFYLLPKLH GILKTLCLEC VLSRADVIPD IFLQLKSSGF IQMMSHRDEA
RQRVCLDIIH KIIALLTPVE LQELLGAVTT FVSHPSPVCK ERMYEILMWI QDNYGDEESM
KDKTSLEILD AAKETLLQGL SEENQGLRLY VRNFWSQEKR LPSATLERML TVLRSLYSCQ
IERCFLSLAT NLLLEMTSQS PDFTRNMFEY PLSECTYQDY VIDSNWRFRS TVMTPMFVET
QSSQGPESAG ASQSGSMKGK LRATQTSLEF SQTQAPGTAG RRKAYNWLTG SSVDTLADYS
ASTESLSSLL VFDKKSERQA AARRPVGEGF GLRRLTASTD EVDSRTRAEN EQRSNILRLR
RRFLKDQEKV SLGFAQKEIQ QQRQRKEEKA DQRLRKEAQV TLYRNYRVGD FPDIQIPYSS
LIAPLQALAQ RDPILAKQLF SSLFAGILQE MDKTHTPHDS GRIKEELRCN MNTFLNKSTL
CFPPFIACVQ DMCYQQRELQ QLDPAAVSST CLVSLQQPSG ILLLEEGLLH AAEPEERPAK
RARGRREIPP DTNKWIHLAR LYRDLEDYDV VRGIFGGKVG TKSITCSALQ AEANTDFAEA
VKLYNEALNT EDWPDGEPTD SEKDFWEIAA MEAYNQLTEW KSLQYCSTVY IDENSPPNLE
RMWSEPLYQV DMYLQHMIRS MLKQLQLGES DQTLLSFIDK AMRVEERKKL LESHHSQELS
LLYILQEDYD RAKYYTNHAM QLFMESYSSV DTLLTQSRLA VLQPVQALTE IQDFLLFIKG
DVSVGSLKSL IRSWTDRYPD TKVDPVIVWD DIITSRCFFL DKIREKLRGD SMEVDEAQDP
ARNVETIVND CKFTMKLHMA DSACQQKNFP VTTKLLKELH KEAKSNREWL LRWVHSFSSY
NHKRSRTQGA IEQIGTMLKT IPLLGNRSAT SEVFRRQKIL QGTSFHILAS AVGRSPSVLG
TLAAEKQESV VRLSGAAKPM EVGLQQHALK LLCEASRKAD EELQSFAHDF VETSSVSETY
MALANFCDKL LREEEQDDTV SQFPDLVALS VHVVESMLKA LKMNCEEARL RFPRLLQIIE
LYPSETLDVM TKEMASIPCW ILISWISQMV ALLDKPEAIA LQHCIEQIAR SYPQALVYAL
MISSESYRFE ESVTGHQQQE FVNRLRSMLD KGGAVKSFVD ALQQLTNPDM IFKDWWESVK
SEMEKSTFNK KQMGEMYEEM RSSLCDRNTQ GHGGFRRKFI QKFSKDVEKL LGPNGSNLFE
KRKNKSFLQE VTKLMESMRG FQKEPGNLKE YSPWLSGFKA DPFSNELEIP GQYDGRSKPL
PEYHAKITGF DERVKVMSSI RRPKRLIIRG DDERDHPFLV KGGEDLRQDQ RIEQLFAVMN
IVLSHDTSCT RRGLQLRTYQ VIPITTRIGL IEWMENTCTL KEFLENTMTG DEQQKVQRCA
EIYHKWLSTF GEAPSISLYG LSYRKAKRDN AVGNFLKVLQ HVPSDLLKRA FLKMCNGPEA
FLSLRSHFIT SHALLCVSHW VLGIGDRHRS NFMINMETGG MIGIDFGHAF GSATQFLAVP
ELMPFRLTQQ FVNLIQPLKE SGLIQSTMVH SLRAFRAEPD LLLNTMDVFV KEPSLDWKNF
EVKQLKKGGT WTQSVNTKEI NWFPLQKVNF ARRKLEGANP ATITSEELKL GFEKDFAFQG
MQAVALGSEE HNVRAKLPAA GLSVEQQVDC LLDQAMDPNV LGRVYAGWEP WI
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