ID M3ZIR8_XIPMA Unreviewed; 592 AA.
AC M3ZIR8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Transmembrane anterior posterior transformation protein 1 homolog {ECO:0000313|Ensembl:ENSXMAP00000002110.2};
GN Name=TAPT1 {ECO:0000313|Ensembl:ENSXMAP00000002110.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002110.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002110.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002110.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TAPT1 family.
CC {ECO:0000256|ARBA:ARBA00008803}.
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DR AlphaFoldDB; M3ZIR8; -.
DR Ensembl; ENSXMAT00000002115.2; ENSXMAP00000002110.2; ENSXMAG00000002104.2.
DR eggNOG; KOG2490; Eukaryota.
DR GeneTree; ENSGT00390000010628; -.
DR HOGENOM; CLU_003655_3_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR InterPro; IPR008010; Tatp1.
DR PANTHER; PTHR13317:SF4; TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG; 1.
DR PANTHER; PTHR13317; UNCHARACTERIZED; 1.
DR Pfam; PF05346; DUF747; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 466..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 67283 MW; F9298108C2D4A251 CRC64;
MADVLGTELS EEKENEIELK KRQKRPWEEF RRSGKIGITP ELPETLGFFD ISAVKREQQE
VSADPSLTRF ICTELTRGYF LEHNEAKYTE RRERVYTCMR IPKELEKLMI FGFFLCADAF
LYIFTLLPLR VLLALLRLLT LPCCGFSGSR LLQPAQVCDM LKGLILVLCF SMMHYVDYSM
MYHLIRGQSV IKLYIIYNML EVADRLFSSF GQDILDALYW TATEPKERKR DNIGVIPHFF
MAVFYVFLHS ILIMVQASTL NVAFNSHNKS LLTIMMSNNF VEIKGSVFKK FEKNNLFQMS
NSDIKERFTS YVLLIIVCLR NMEQFSWNPD HLWMLFPDVF MVVMSEVAVD IIKHAFITKF
NDITADVYSE YRASLAFDLV SSRQKNAYTD YSDSVARRMG FIPLPLAVLL IRVVMSCVKV
QGALSYLCVF LFYLGMVTLK VLNSIVLLGK SCVYVKRANM EDKLFERPPT APSFSAKSPS
KSDPRRCAKS SGESSVDQIP VTPCSPPTSS SSSVTTQPAP RPDLFLPPPT DASPATADSC
PSTSEPQSDA EPPTASPLQE EEADEASDMN HRAPNKDLLE IDRFTICGNR ID
//
