ID M3ZIT3_XIPMA Unreviewed; 1172 AA.
AC M3ZIT3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Zinc finger E-box-binding homeobox 2-like {ECO:0000313|Ensembl:ENSXMAP00000002125.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002125.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002125.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002125.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M3ZIT3; -.
DR Ensembl; ENSXMAT00000002130.2; ENSXMAP00000002125.2; ENSXMAG00000002123.2.
DR eggNOG; KOG3623; Eukaryota.
DR GeneTree; ENSGT00950000183208; -.
DR HOGENOM; CLU_005890_0_1_1; -.
DR InParanoid; M3ZIT3; -.
DR OMA; MAQSPRW; -.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 197..225
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 268..295
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..669
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 957..984
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 985..1012
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1013..1041
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 611..670
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 129782 MW; 1DE63AB530669443 CRC64;
MMAQSPRWKR RKQLNPRRKS VLNYDSVLET TSETDEDDQT LLRDDCSFTG GAGDDEEAGS
PVAVPALEAS PRVGHALLSN REPDDSEHRG EDECIDDRSS EYDALGPEAS LQAVEDSAGR
RLDGISGLDE FFLKRKLGDD DGHQATIAEY LQRSDTAIIY PEAPEEVTRL STPEAGGQDE
SEHDLPSSAT DDFAQLLTCP YCERGYKRLT SLKEHIKYRH ENTEETFTCL LCAETFNQRA
QLERHMTTHK PTVDQPPLLS EGAANRKFKC SECGKAFKYK HHLKEHLRIH SGEKPYECSN
CKKRFSHSGS YSSHISSKKC IGLVALNGRV RNGNNSKPSS SPNSTTSSPG SPALAHLRQK
LENGRLLGLQ DQQGQVDIKT EPMDFNDYRL LMASQHGFGG PGVYLNGRSG SPLGIQGSSQ
NSFQHLGGMG IDLSLLGYAG PLGSSLSEVQ KVLQIVDNTV CRQKMDGNPE ELSKLRAYMK
ELGAQMEAHA SFQVIGSNSP TKSIIDYTLE KVNEAKNLIN DSKMQVDVKK EKPNQSVDLS
GEEKFSDGQN QFLTFSCQYC KEIFPGPIPL HQHERYLCKM NEDIKAVLQH PEGSPVGCRG
LRADELSRTE RPHSPTNLFK DHMSVLKAYF AMNADPNSEE LLKISLAVGL PQELVKDWFS
QWKIQNNHMD SLRKKFPTPE RGRPDCSLSR SPGSLPVIDL HNGFINTDPT HRLTKINQFT
ANRQTKGDKP IDPADSLRSN TSSPLNLSST SSKHSQSSSY TPNSLTSEDA HGDTPLDLSL
PKHMAQKRPK PNGFITEHNG EVSVREQGSG SLALVKIKKE VLGSDSGGSS IHQLEKSTSP
IFGINPFAGG PMYTSLPPHG AFPPPTFISP AQATIPGLRP YAGLDPMSFL PHMAYTYATG
AATFAEMQHR RKYQRKAGFQ GELLDGTADY LSGLDDLTDS DSLLSRKKIK KTESGMYACD
LCDKTFQKTS SLLRHKYEHT GKRPHQCQIC KKAFKHKHHL IEHSRLHSGE KPYQCDKCGK
RFSHSGSYSQ HMNHRYSYCK REAEEREAAE REAKVGGLAG GLEPTELLMR RAYLQGLGPL
GYSDPEEQPE DGGGTILRDG REGGGREVGG VDNKMYEEVT DGQEASFRNR EEEGDSRSQM
DSMMDEGGKD SAQLMDTCSR EGKTDGTLEQ ED
//
