ID M3ZJ21_XIPMA Unreviewed; 384 AA.
AC M3ZJ21;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Methyltransferase like 4 {ECO:0000313|Ensembl:ENSXMAP00000002213.2};
GN Name=METTL4 {ECO:0000313|Ensembl:ENSXMAP00000002213.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002213.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002213.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002213.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR AlphaFoldDB; M3ZJ21; -.
DR STRING; 8083.ENSXMAP00000002213; -.
DR Ensembl; ENSXMAT00000002218.2; ENSXMAP00000002213.2; ENSXMAG00000002213.2.
DR eggNOG; KOG2356; Eukaryota.
DR GeneTree; ENSGT00390000016237; -.
DR HOGENOM; CLU_027091_1_0_1; -.
DR InParanoid; M3ZJ21; -.
DR OMA; WVTNRQR; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0140640; F:catalytic activity, acting on a nucleic acid; IEA:UniProt.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829:SF4; N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4; 1.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
SQ SEQUENCE 384 AA; 43057 MW; 900F1D785E41B74B CRC64;
MSVVLQSNSG WVLDSQSLID RGYTRCITWT GHQKPHVKCN FKRQCFHILK SHYNMSGRVD
GGHTVMAQKT EKSAKVDCLS CSIILEGTKA LVDSAQSLGY LSGETETSQD PLPSQDCRLA
ALCEIAKELP LVADEEQEWT QSLLTEEGGA SHVDLFSQVT ENSQAWAAVV PLIGEEYIIP
PNTAFLLSDF TRIQPLVQCG RRFDVIVIDP PWENKSVKRS RRYSSLPSSQ LKRLPVPLLG
SPGCLVVTWV TNRPSHLRFV RDELYPHWGV EVVAEWFWVK VTTSGEFVFP LDSPHKKPYE
VLVLGRPLQT ANVPVEDKRL IVSVPSALHS QKPSLSEVLK LYVGAEAKCL ELFARSLQPG
WTSWGNEVLK FQQIIALPRG RNIW
//
