ID M3ZJE5_XIPMA Unreviewed; 1824 AA.
AC M3ZJE5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=MAM and LDL receptor class A domain containing 1 {ECO:0000313|Ensembl:ENSXMAP00000002337.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002337.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002337.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002337.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014324092.1; XM_014468606.1.
DR Ensembl; ENSXMAT00000002342.2; ENSXMAP00000002337.2; ENSXMAG00000002333.2.
DR GeneID; 102221902; -.
DR KEGG; xma:102221902; -.
DR CTD; 340895; -.
DR eggNOG; KOG1095; Eukaryota.
DR GeneTree; ENSGT00940000165597; -.
DR HOGENOM; CLU_002270_0_0_1; -.
DR InParanoid; M3ZJE5; -.
DR OMA; YMGDVVI; -.
DR OrthoDB; 2905895at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00112; LDLa; 9.
DR CDD; cd06263; MAM; 7.
DR Gene3D; 2.60.120.200; -; 7.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 10.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF142; MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00629; MAM; 7.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00137; MAM; 7.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS50060; MAM_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1824
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017455366"
FT TRANSMEM 1705..1727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..217
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 265..429
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 476..649
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 712..878
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 927..1086
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1142..1298
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1349..1513
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1649..1683
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1756..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 26..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 33..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 45..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 229..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 236..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 248..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 457..472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 694..709
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 886..898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 893..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1106..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1113..1131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1125..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1314..1332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1326..1341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1544..1559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1573..1585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1580..1598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1592..1607
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1673..1682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1824 AA; 201764 MW; 8C9DD50ECE7358A9 CRC64;
MALLLGTVWL LLALNLLISS VFVSACSHQE FTCRQGFCVA LDSVCDFTDD CGDGSDEENC
STYTRCDFEE SFCDLIQNSE SLYRWTRTAE APGLKQDHRN TSAHFLSLSP IGGKKITAEL
RSPVFLPTHG CQIRFYHYAG TGHGELQILL QPHLVAQSSE LWKHSFQLEK GTWLRAVVHF
SSNQRFQVVI RGELSASSEA SEVLAIDDLS FSPGCVILPE GRVLTSLPCP PSWFTCARGR
CIEESKVCDF TPYCPNGEDE ARCPSECDFE DGSCGWYELT PGDGFDWIRG SSDKVPPDYY
DHPPLPDHTT NSTKGHFMFI LKNSSSLHPN AVLIGPWFQQ SASRCTMTFW HYNSGISVGA
ADIYLRFKGV QNKTVIWTTL YDQGRLWNRV TIQLGRITQP FQIALAKISL GVFDGVSAFD
DVSFKNCSMP PAVAVCPKHT HFHCLHTKAC VEHLQLCDLV DDCGDGSDEE GCSPEIQCDF
EDGLCNWKQE TSGGDVFNWT RIQGPTPTQN TGPWKDHTLG NTSGHYLYIE SSLPQEFKDT
AVLLSPVFEP TDQPGKDPAW SPHRRCAFRF HYCMFGSHVF SLAVYMRTTT TDRGMLLWAK
YGNQGNLWHR KTMYLNSVQP FQILIEGTVG DDFEGDIAID DLSFLDCQLF HGELPSLITP
PLTTPAPTVI PNNCSKGQFV CGTHGECVLL SQVCDFKQDC SDGSDETNCV KERCDFEGGV
SCGWTVVSPS SSVNHVFRWA ADQGESSHDG EQNHRPTNDH TLNSPKGWYM YADSSNGGYG
QFSDLQTPVI SSTAPQCTLI FWYHMSGFTV GTLQVLLRHK NVTHVVWSQT GNQGNRWKRA
EVFLGLLNDF QVVFRAKRGI SYMGDIVIDD VSFQDCSPIL PSGQPCTSEQ FACANSHCIP
QDNLCDFINH CGDNSDEDPF ICKGFSGRCN FEFDLCSWRQ CQEDDFDWLI KAGSTPTVGT
GPSSDHTLRD PAGHYLYLES SFPQAVGDAA RVIGPLLSRR SSQCKMRFYY HMSGDGIGTL
SVFTKTEASL HLLLNLTGDQ GNYWQMKELQ LSSSADYQIV FEGKVGRSEK GDICLDDITF
SPGCLLSPSV LVIDSTPPPA PPTGFCPPGA SVCGKGSCYT PEQMCDFTYD CSDGTDEKDC
GTSCSFENGR CGWKSSLADN VDWALGTGSV QRIRPPYDHT LMDENGHFVY LEATPLGLKG
DKAHIRSSVW KESSAVCKLS FWYYLSHKAT GTIRLLIKTE NSLIEMWKKT GHQGNQWIQA
VVPLRNLRNF EVIFEGIRSS DVSGGAALDD LEYIDCAPSA MEPGGCPAVT DFVCESGHCI
ESHLVCDNKA DCADESDEKD CDYIFGLPGA CNFNMEDDRW EQICQLSQDP DDDFDWMIGH
RTEIGVGPQS DHSPDGGGNF LYIHSGTQRE GDVAKVMTMN PFPASIGLCH LRFWFFMYGS
TTMGTLKVYT VGPNGTPLLM WATTGNHGNQ WTYANVILSN TKDFRVTFQA KVGGDMWTDI
ALDDISYTAE CVVGGPVTPQ PLTCDTEQFQ CTHSFQCISK SWWCDGSPDC ADQSDEERCP
TALPGTVPPQ GDCPDENFQC SDLLCLPALL RCDGVYDCPN GEDEHGCPLL QCEPGELVCE
SWPGCVPLHM RCDRSSDCQP FHSDESSCHE CPPTYCQDRG SCHLEENGPL CLCEPGWSGN
RCHVKEKPFL TTSSPTVEAT QLDSVYAGIG IGSVLLLAGF AVCFLALCKK KCGFIKADPM
KYGVMDNPSF EWRAENLSED KSPDSGPSIN PKTSDGLGLP ISVYPWRREV EQGSNWKDAK
LSFSNPMYNY PCDTNGAGNR SAEE
//