ID M3ZJN0_XIPMA Unreviewed; 1325 AA.
AC M3ZJN0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRC {ECO:0000313|Ensembl:ENSXMAP00000002422.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002422.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002422.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002422.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000002422; -.
DR Ensembl; ENSXMAT00000002427.2; ENSXMAP00000002422.2; ENSXMAG00000002421.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000159457; -.
DR HOGENOM; CLU_001645_2_2_1; -.
DR InParanoid; M3ZJN0; -.
DR OMA; YTCEVQP; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14557; R-PTPc-C-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF539; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 665..924
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 844..915
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 956..1231
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1145..1222
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 33..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1025
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1325 AA; 148959 MW; 93FECF5D3C0F4BCE CRC64;
MAGLRGLMIL LVLMVGLACC QNNAATLPPH TGTSYVSSVA TSPPSISATP TAATSKPPPI
IKPTLTSLST TSKPPSSSTK TTDETQASSQ SPPQNSTPPA SISNENPTTK KSSSQNSTSP
PVTQPNTTTA ATTAEPQNDP KCSYSVEAIL FGFQIKMTDS APDNYTVHVA EKGSSFQKTT
TFQMDNKTST HKINRLKPCT EYELTVKFNS SNGTEIFCNT IKNEITTTGM TEKDIKNISC
SPGYFCYKSG WDISSVLSKN IRDLIEDFDN NGSYCFKPAY QSICSELVLK FPAEKCTNVT
FTITENVPFD FIDLHNVLQS EPDKLPAKIN STLPSKCQNL SVEYKCSGIN NDSVQLSDMK
PFTDYSCTGD IKMNNVSINK TLSPVQFNID CDFSVSNLQF KKTNTSIHLN WETTSHACQD
ILDKLTELSH SCSCQLKEGE RYVKAENKKG LQVDKRTCYI EGLKPYKDYI CNVHAIYNKT
RKFEDTSIQV KTEPGIPVLN AEFQVHNPVN NAIKVSCKHK NIELNGPKKS YIANLHGFPA
KKVESPSCDF EFTDLSYLTS YTVEVAISNG HFQSTPLKTS AATLYNDKAL IGFLVFLIII
TSVALLLVLY KIYVLKHRKS HDMTENMLLI AQGNDEDSLM PVEPIPAELL LETYKRKLAD
EGRLFLGEFQ SIPRIFSRYV VKEAKKGCNA PKNRYVDILP YDYNRVHLTT GNGEAGCDYI
NASFIDGYKE PKKYIAAQGP KDETVSDFWR MVWEQQSSII VMVTRCEEGN RIKCAQYWPS
LDRETEIYEE FIVKLTSEEH CPDYTIRHLS LTNKREKNLE REVTHIQFMS WPDHGVPGEP
HLLLKLRRRV NAFKNVFSGP IVVHCSAGVG RTGTYIGIDA MMEGLEAEGR MDIYGYVVQL
RRQRCLMVQV EAQYILIHQA LLEHNQFGET EIALSELHSM LNTLKQKNSD SEPTLMEEEF
ERLPSFKNWR TCNIGMTEEN KKMNRSSSVI PYDYNRVLLR TGEDNSQDSE VDDEEPEDSS
DEEDEDSIRY INASHINGYW GSRSLIAAQD PLPDSFTDFW LMVHQKKLST IVMLSEHKED
GEPLYWRKEK ETFGDFEVEV SSTEITPVFI TRTMLVRHVK RKDSRQVKHF QFLKWEGTGL
PEKPQELVDM AKEVQRSCVG SKSQRMPILV HCNDGSTRSG IFCGLWNLLD SAETEKLVDV
FQVVKTLRKD RKGMITSLEQ YQFLYKALEG AFPVQNGEVK QVKSAAVASV EIVNETKAGE
AEAEKQPEEK KAEEPDSTTS SNQQAEAEST PLVAESEKEK KEEEPAKEST PQEESSNGPT
VTVEV
//
