ID M3ZK74_XIPMA Unreviewed; 550 AA.
AC M3ZK74;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=AT-rich interactive domain-containing protein 3 {ECO:0000256|RuleBase:RU369100};
DE Short=ARID domain-containing protein {ECO:0000256|RuleBase:RU369100};
GN Name=ARID3A {ECO:0000313|Ensembl:ENSXMAP00000002616.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002616.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000002616.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002616.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor. {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369100}.
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DR RefSeq; XP_014324934.1; XM_014469448.1.
DR AlphaFoldDB; M3ZK74; -.
DR STRING; 8083.ENSXMAP00000002616; -.
DR Ensembl; ENSXMAT00000002621.2; ENSXMAP00000002616.2; ENSXMAG00000002619.2.
DR eggNOG; KOG2744; Eukaryota.
DR GeneTree; ENSGT00940000160899; -.
DR HOGENOM; CLU_026952_3_0_1; -.
DR InParanoid; M3ZK74; -.
DR OMA; HIHKIKK; -.
DR OrthoDB; 445024at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd16878; ARID_ARID3A; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348:SF1; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A; 1.
DR PANTHER; PTHR15348; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU369100};
KW Nucleus {ECO:0000256|RuleBase:RU369100};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transcription {ECO:0000256|RuleBase:RU369100};
KW Transcription regulation {ECO:0000256|RuleBase:RU369100}.
FT DOMAIN 210..302
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 415..509
FT /note="REKLES"
FT /evidence="ECO:0000259|PROSITE:PS51486"
FT REGION 66..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 60322 MW; 01DCDE679B606D5E CRC64;
MKLQAVMENL HRQQRAKLLM EQQLQQQAIA QHAQVRAGND PMESAAPEGE QAQIAALAAM
RAAAAGLQRV SDSPMSKRSS GGEEERDDDN DEGEEHYKDM MGSDEEEQIK RKWDEGDFES
DMDEDFDDDL AEEGLPTGHD AVAPGKGILV LPHRHLHPHS QLPKVRPSVE QEPRVAIMPP
HAPHSHLGVQ DHGEWTYEEQ FRQLYELDGD PKRKEFLDDL FSFMQKRGTP VNRIPIMAKQ
VLDLYMLYRL VTEKGGLVEV INKKLWREIT KGLNLPTSIT SAAFTLRTQY MKYLYPYECD
KRGLSNPNEL QAAIDSNRRE GRRQSFGSSL FTYSPNGTPT MLSSPKVSTP NVGLTVGTNG
ASLTPMQKIK KEEEGGQPLP GVGIPRLPVG PMPGHSVAAV QAAAAAQAAM AAQVAALEQL
RDKLEAGEPP EKKMALPAEE HHRLLQRALQ HNLLAMTAQI PMNIRINNQD GRQESALNLT
TNGTNSISMS VELNGVVYTG VLFAQAAAGS ASSGASVSSL SNKSVSSRIA PQQQQQQQNT
PTSASSNQLS
//
