ID M3ZN40_XIPMA Unreviewed; 559 AA.
AC M3ZN40;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Acid sensing ion channel subunit family member 4 {ECO:0000313|Ensembl:ENSXMAP00000003633.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003633.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000003633.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003633.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins.
CC {ECO:0000256|ARBA:ARBA00038726}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC4 subfamily. {ECO:0000256|ARBA:ARBA00038140}.
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DR RefSeq; XP_014327457.1; XM_014471971.1.
DR AlphaFoldDB; M3ZN40; -.
DR STRING; 8083.ENSXMAP00000003633; -.
DR Ensembl; ENSXMAT00000003638.2; ENSXMAP00000003633.1; ENSXMAG00000003624.2.
DR GeneID; 102221668; -.
DR KEGG; xma:102221668; -.
DR CTD; 407668; -.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000159052; -.
DR HOGENOM; CLU_020415_1_2_1; -.
DR InParanoid; M3ZN40; -.
DR OMA; IHEYCDY; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690:SF13; ACID-SENSING ION CHANNEL 4; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
FT REGION 474..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 63033 MW; E0648AE017049725 CRC64;
MPIEFVCKIK FAEEDEKQKS RQDGDKESLI EESCTPPAKD LAGFANSCSL HGINHIFVSG
RLGIRQTLWA LAFLTSLALF LYQAAKCAIS YLEHPHVTAL NEEATPEMVF PAVTICNINR
FRFSALTDAD IYHLANLTGL PPKNRDGHKP TDLMYPAPDM QDIFNRTGHQ LEEMLMSCNF
SGQNCSVEDF SVVYTRYGKC YTFNGNKTTS KKTKQGGMGN GLEIMLDIQQ DEYLPIWRET
NETSLEAGIR VQIHSQDEPP YIHQLGFGVS PGFQTFVSCQ EQRLTYLPQP WGNCRSTSRE
KFPGYDTYSI SACRLLCETN EVMRVCNCRM VHMPGTADIC PPSKINCVDK ALAQLQKNSG
DICPCETPCN LTRYGKELSM VKIPSKGSAR YLSRKYDKSE DYIRDNFLVL DIFFEALNYE
TIEQKKAYDV AGLLGDIGGQ MGLFIGASIL TVLEILDYIY ELIKHRLQRL LRPQKEEKKN
TQPTTTVATV GLEEMKAKEP NDTTRSHPEG AYANTILPNH HVPHPHPHPH PHPHPLSHPL
PAPHQHRPGH HGIFEDFAC
//
