ID M3ZNC4_XIPMA Unreviewed; 1003 AA.
AC M3ZNC4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Synemin {ECO:0000313|Ensembl:ENSXMAP00000003717.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003717.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000003717.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003717.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_005802088.1; XM_005802031.1.
DR AlphaFoldDB; M3ZNC4; -.
DR STRING; 8083.ENSXMAP00000003717; -.
DR Ensembl; ENSXMAT00000003722.2; ENSXMAP00000003717.2; ENSXMAG00000003710.2.
DR GeneID; 102220528; -.
DR KEGG; xma:102220528; -.
DR CTD; 23336; -.
DR eggNOG; ENOG502QTUH; Eukaryota.
DR GeneTree; ENSGT00940000159268; -.
DR HOGENOM; CLU_002793_0_0_1; -.
DR InParanoid; M3ZNC4; -.
DR OMA; KMLYASE; -.
DR OrthoDB; 5353519at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR030634; SYNM.
DR PANTHER; PTHR47136; SYNEMIN; 1.
DR PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 11..319
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 389..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 114516 MW; C98400535B87A487 CRC64;
MLPFKRTFDS EKQQLQKLNS RLAQYLSRTK QLEQENALLI AEINKLKRGS GTAEWEQRYK
ADMKDLRRMV GQISFEKSQA EMEREKLWRE LQTVRSLCSE QTEACRDISG ELKGCEQELQ
QAHKINSDLQ QRLLQLESEY KRLEDAHRHE TANLRHQVES RVVPIITQTY HGPPVVSVEE
VQEYARGLSE GWIETFDMYQ QKVEEMEQSI KADQVRLCDL QKEKMLYASE LGKLRTEAEK
QGQVQMRLEE ELMHMQDKFR VDLSEHQIII EQLEHERNIL AEAMEEKMRE HQHLLQVKMD
MGMEVAAYRT LLESERVGMQ GAHRRMTQHQ RERIIDIKVP AQHYSPRTST LTSRRHIDMR
YASPTNLRRP PVTSSGSISP SRVIPISVAG RARHQSPASR RDMISFNKAR AATSVPTTST
ETGQDKNKIS KPAQKTVAEE KTMRFKQVPY ESKASFSPET KSVRVVSPPA KSIAQTVTES
KRQVSNEKEK GYDPDEFKDK EKAETIIEKK ILDSVSVEEI IEKVIKPAGL EAKACSSGDS
KVRYHVEKSE QEDGTTKTQI VLESKFKEEI DVSEDSALEE FLSHGVKKVS MEDIEDTATG
NMIKNLISSL QGGENMENKS VNVEIIEEPI ESFSDEELEI EINRKPSSYE PSRYFQIEEM
ENITHDSEEE KSEDNATIAS KRGTNQPSGG SVHIQEFSRE NTSPNFSREQ EFHEYFVSTP
DENLSEPEDG GGIMSYGHYG IVDDLSDERY YQDESLPQRK VIVEESEEYQ YKSSNHSIPK
ESFPECIIEE EVRVSPIVQE SMLEFLREDS LEPKEQLKGA LETLQSSVSG PLREELVFLT
KMSSESPQNV AIKKVEQSSD NGTMTIVAEL NVSQTLEDSG LLEEGDDISE EQIMKALRSS
NLDLEKAFQG GASSGYSIRV SKEEGVSYAE GLEGFGSLEE SASKIIEKHI KLEPSEKSFT
FQMEEQGDHG EESSEQSQLL KNPEKISTEK RVAIVYLERP LED
//
