ID M3ZNW6_XIPMA Unreviewed; 857 AA.
AC M3ZNW6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Leukemia inhibitory factor receptor-like {ECO:0000313|Ensembl:ENSXMAP00000003909.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003909.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000003909.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003909.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M3ZNW6; -.
DR STRING; 8083.ENSXMAP00000003909; -.
DR Ensembl; ENSXMAT00000003914.2; ENSXMAP00000003909.1; ENSXMAG00000003899.2.
DR GeneTree; ENSGT00940000165259; -.
DR HOGENOM; CLU_309706_0_0_1; -.
DR InParanoid; M3ZNW6; -.
DR OMA; GKMMQYN; -.
DR OrthoDB; 5347052at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF191; LIF RECEPTOR SUBUNIT ALPHA A-RELATED; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..857
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004046401"
FT TRANSMEM 685..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..397
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 398..490
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 805..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 95773 MW; 0532F1FA8D3F4500 CRC64;
MIRFWFLLLV LIRLSQQNQT GVSSCGPQNL TVSRSDQTVL VEWEDDPSCS ALNDPILYNM
TVLVENQEVH SDGVWVAPGH VGSTHSWRWT SPLPMDCAAH TFRLRAQIQN QTSRLDQERT
LPDKDTFSRN VFPQDALLEA GSSATFCCIV PHGQQFGQMY LDGNTGNTTK ISEHRYALTV
RLKPVMESGA DVHCETKSGE VHGASVFIGY PPGDEDLRCE TRDLESVECR WNKGRNTMVE
VQSRTRYELD GSPCVIGSEL RCSKEVNIGG GERNWTLTAQ NVFGKVEIQD SADLTRRVHM
FAPHDLGVGD VEARSVRLSW SWTVQRYHNL SLNCQMIVSD ADGSSLQIKH GVGLKAAVLT
DLRPNWKYEV KVRCRTAQHF WTWSDWSSRV SFLTEGDVPD ALDVWMQRKG SQTAIVWKKL
LANQSHGDVT GYHVTWTRTR GSDQLHKEEV NASVHEYTLD GDSVVTVTAK NQHGSSPPST
ITVPPTSPDE TSMNLSCFTG SDGGLDLSWS HHPEASCGYM VDWFPALEGD RVDWLKLPPS
QNRVRIKPKN DVAGRRYSVS IYACTGGAPL LLERKDGFFT EKQIQPKLFQ PLSYKLRGSD
VEIYWDPVPL REQPACIHGY VLYYFKNRGE PISVTTENPA DSSLTARNLQ SGSYTFIMAA
QTAGGAYGNT TLQVLLNDED DLSNIFISMG AVFILLFLIT VLCYRHWACI KEKFYPDIPK
PNMADWFTSP EKRVNPYLQS GLGCHGEENL AVPELLLKPA ELLNNNNTDQ EDTALTSQAP
PLYQNNPAQS RHAVSTVFPN LTYNLPAADP ERPADPGRPA GLEPNDYHPQ TLAEVFGQNR
AAQKPVICVS EYIMALQ
//
