ID M3ZPA9_XIPMA Unreviewed; 673 AA.
AC M3ZPA9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Zinc finger CCCH domain-containing protein 14 {ECO:0000256|ARBA:ARBA00015071, ECO:0000256|RuleBase:RU369058};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004052.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004052.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004052.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in poly(A) tail length control in neuronal cells.
CC Binds the polyadenosine RNA oligonucleotides.
CC {ECO:0000256|RuleBase:RU369058}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|RuleBase:RU369058}.
CC Note=Colocalizes with poly(A) RNA in nuclear speckles.
CC {ECO:0000256|RuleBase:RU369058}.
CC -!- SIMILARITY: Belongs to the ZC3H14 family.
CC {ECO:0000256|ARBA:ARBA00008423, ECO:0000256|RuleBase:RU369058}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M3ZPA9; -.
DR STRING; 8083.ENSXMAP00000004052; -.
DR Ensembl; ENSXMAT00000004057.2; ENSXMAP00000004052.2; ENSXMAG00000004041.2.
DR eggNOG; KOG3702; Eukaryota.
DR GeneTree; ENSGT00440000038430; -.
DR HOGENOM; CLU_022605_0_0_1; -.
DR InParanoid; M3ZPA9; -.
DR OMA; HPKCKFG; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008143; F:poly(A) binding; IEA:UniProtKB-UniRule.
DR GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:UniProtKB-UniRule.
DR Gene3D; 4.10.1000.30; -; 1.
DR Gene3D; 4.10.1000.40; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR040366; Nab2/ZC3H14.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR14738; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR PANTHER; PTHR14738:SF29; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR Pfam; PF14608; zf-CCCH_2; 5.
DR SMART; SM00356; ZnF_C3H1; 3.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369058};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369058};
KW RNA-binding {ECO:0000256|RuleBase:RU369058};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 547..580
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 547..580
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 177..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 74190 MW; D4CA84824C0846B0 CRC64;
MEIGTEISKK IRAAIKSKLQ ELGAYIDEEL PDYIMVMVAN KKTSQQMTED LSLFLGNNTI
KFTTWLHGVL EKLRSVAGEP PSLRHLQSDS VTVYGKPSID ENGRAEDLKL LAVSSSWSDR
MEVPVSSSAY DSRKGLLGKG FSRHTSTIKP HTEPLPSEAV IDIKPEMDDD LIAEEPVEVG
NGRTRSAGRP TVEIYRPGQS KFTSMSSLEM CRPPEGSSSM RQQDGRSSKA SRTGLSKQEE
MTRKRKAPVA SSVVRVNRAD DEDSDDAEDD DDDASFGGRS LSSRVSLPSK PERKPTLPPA
KQANRNLILK AISEAQDSIT KTTSYPPIPQ RQTVPVAPRT RLASSEEMTA ALQLMQNLHS
LAPRAEAYAA ADQPASRTTT RSLASRLQLD GSGARQQSEY GAEAPAGREP KTSDTRSFIM
SRPVIEEASA RSQQQVQPPA LPRTVQAREG VDTSSPKFIV TLDGVPSPLG NLTDGDMELD
DMRPLSKVTE AAGHVYRESK VSVLDRLQGV VTSSEDGRMD ADMADEDDVP MKKQKVLERC
KFWPVCKSGD ECMYHHPTAQ CKTFPNCKFG DKCLFVHPNC KYDARCSKPD CPFTHVSRRG
TVAPPLRPVV QQSSSGTVCR FFPECKKVDC PFYHPKPCRF ATQCKRAGCT FYHPTTAVPP
RHALKWTKDR AAN
//
