ID M3ZPL6_XIPMA Unreviewed; 1547 AA.
AC M3ZPL6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Homeobox protein cut-like {ECO:0000256|RuleBase:RU361129};
GN Name=CUX2 {ECO:0000313|Ensembl:ENSXMAP00000004159.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004159.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004159.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004159.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR STRING; 8083.ENSXMAP00000004159; -.
DR Ensembl; ENSXMAT00000004164.2; ENSXMAP00000004159.2; ENSXMAG00000004131.2.
DR eggNOG; KOG0963; Eukaryota.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00940000160241; -.
DR HOGENOM; CLU_005104_1_0_1; -.
DR InParanoid; M3ZPL6; -.
DR OMA; FHNYSRM; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 3.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR PANTHER; PTHR14043:SF5; HOMEOBOX PROTEIN CUT-LIKE 2; 1.
DR Pfam; PF02376; CUT; 3.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 3.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 3.
DR PROSITE; PS51042; CUT; 3.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361129};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361129}.
FT DOMAIN 562..649
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 930..1017
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1095..1182
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1224..1284
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1226..1285
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 148..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1425..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 222..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 332..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1547 AA; 168887 MW; 57DD422980703989 CRC64;
MAADVGSMFQ YWKKFDLRRL QRELNSVASE LASRQEESEH SHKHLVELSR EFKRNVPEEV
REMVAPVLKS FQAQVVALNK RSKEAESAFL GIYKQLIEAP DPAPLLEASQ SLEERLQQLQ
SSAPDSEALV REIRHWRKHL ECLEKTALCT SPEPTEDGSA APAAPEEASE SGSPASLMTP
NSTPAPEAPG SPQQNHQDQT DDRREEEEEE EEGADVSLAD RLSEAEEKIK VLHSSLNAAQ
TELLELRCKY NQEMANKKAE VDAIVANLEK ANQRAEMAQR EVERLKEQLA SGPATVAGSC
HPAEGATRDK KEKSELLSAQ VEAALLAKDR EILRLLENIQ RLQFTLQDVQ ETSSNQILEL
ERQLAYKTEA IERLEAKLQS QMDYEEIKTE LSILKVMKLA SANGSSSQDS AKAAEALLLD
KDVFLPSHKY TGDKTRLLHS NDDDRSDNTG KEASRPPGSH SSSSQAESRA SPSPGPPTLN
GSSSGHDLPR PFSASPCSGD RMSGDHILHK QLLSPHFKKE GIMAFPTALY AAKVALMSAS
QGSAGAGSMD AGLPSDQSES GSSTAGDEDQ LDTAEIAFQV KEQLLKHNIG QRVFGHYVLG
LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM KQFLSDEQNI LALRTIQVRQ RGSITPRIRT
PETGSDDAIR NILEQAKKEI QSQRGGDGKS SLSSSSGRSS NGAGSSSDET IKNILEQARR
EMEAQQQALM EMEACGRSSA ASSGVQVERL GPPERSRVLP LPISIKQEDG GCIAVCMANS
ISSPQTPLSV LSPAAFVQNI IRKVKSEIGE AGTYFDQHWS QERGAMILSG GGSSRPFSSV
SPSLSSSSSG PPTLSRTWPR LENGDGLANS EEVSNADDEL GLGRPVEVKV ESDTSVSGES
PGPSPGRLSY YPAYIPRALK PTVPPLTPEQ YEMYMYREVD TLELTRQVKE KLAKNGICQR
IFGEKVLGLS QGSVSDMLSR PKPWSKLTQK GREPFIRMQL WLLDQLGQSL SQPPNQGHTQ
DKSPVTAQSC PSPPPSPAES NPSPVAEPVS LSLESSKENQ QPQSLGLGLP SHPEGGKSTS
SLMGLHQPTT PLGIQELVAM SPELDTYAIT KKVKEVLTDN NLGQRLFGET ILGLTQGSVS
DLLSRPKPWH KLSLKGREPF VRMQLWLNDP HNVEKLRVMK KMEKKAYLKR RYGLLSTGSD
SDSPSTRSEC VSPALASLDL CPFSQVKKPR VVLGAEEKEA LRKAYMQEPY PSQNTIEMLA
SQLNLKTNTV INWFHNYRSR MRREVLMGGL PDNDTDAEPN SYSPSVIRSP NSDGEDKRLL
LPSGQTHPGL PLSTTDALPH VKQEATYREE DSMGGREGSQ KEVGVQCFPA TMPLSPLKTE
HEDSASGCRE PHPAGQSPTQ EEGACNQIQG LHLGAASADG LQRANKSRYD GEESGESPID
PVSFKATSEP CRSSLEVSLN SPSAASSPGL MMSVSPVPSS SAPISPSLPN QATSANHGMD
ANPLPPFQSP KLNRSTQRRN EKMANLNNII HRLERAANRE ETLEWEF
//
