ID M3ZPT2_XIPMA Unreviewed; 650 AA.
AC M3ZPT2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Sterile alpha motif domain containing 4B {ECO:0000313|Ensembl:ENSXMAP00000004225.2};
GN Name=SAMD4B {ECO:0000313|Ensembl:ENSXMAP00000004225.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004225.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004225.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004225.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SMAUG family.
CC {ECO:0000256|ARBA:ARBA00008232}.
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DR AlphaFoldDB; M3ZPT2; -.
DR Ensembl; ENSXMAT00000004230.2; ENSXMAP00000004225.2; ENSXMAG00000004200.2.
DR eggNOG; KOG3791; Eukaryota.
DR GeneTree; ENSGT00940000159702; -.
DR HOGENOM; CLU_016365_0_1_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0030371; F:translation repressor activity; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR CDD; cd09557; SAM_Smaug; 1.
DR Gene3D; 1.25.40.170; Smaug, PHAT domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037093; PHAT_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037634; Smaug_SAM.
DR PANTHER; PTHR12515:SF9; PROTEIN SMAUG HOMOLOG 2; 1.
DR PANTHER; PTHR12515; STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 299..362
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 157..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 71097 MW; FEA30AC7BD0A7DFF CRC64;
MMFRDQVGIL TDWFKGWNEC EQTVALLSLL KRVSRTQARF LHICLEHWLA DCTEIHILEA
EANNAATVSQ WHQEPKEKVV SLLLSHLPLL QPRNCEAKCE YMKLLQKVLT HTIESSLFVE
ESRQLLSYAL IHPATTLDDR TSLASWLNHL EEHLSSGYAS RAPPSPYHPR QSSDEWPGSA
EALDPGNAWP DKSPSSSTSP AGQNGHMPFP GGLSSPISGN GNNTGLVGHM QPSPLKKPMQ
VIPSNSLACG SEWGSQDDAG GRQNFISTDH APLSPQSSIA SSGSEQTEEQ GSARNTFLED
GSGMKDVPAW LKSLRLHKYA SLFSQMTYEE MMILTEQHLE SQNVTKGARH KIALSIQKLR
ERQSILKSLE KDILEGGNLR NALQELQQII ITPIKAYSPP SAAQPISDTS TNSTDGTKTG
ADKEATSEDL QSHNPPPCDG DSSVTPISDG DIAGQFTRVM GKVCTQLLVS RPDEENISCY
LQLIEKCLAH EAFSETHKKR LVTWKQQVLK LLRFLLSSGS VSGGVSRRGQ RQFPMTPRGL
PAGRMCLPGG IGGASPRHTL ANPALAGQGR QNLWFANPGG SNSMPSQSRS SVQRTHSLPV
HTSPQTMLMF QQQECQVPGS DLEINPTLES LCLSMTEHAL GDGTDRTSTI
//
