ID M3ZQW6_XIPMA Unreviewed; 358 AA.
AC M3ZQW6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cysteine rich with EGF like domains 2 {ECO:0000313|Ensembl:ENSXMAP00000004609.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004609.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004609.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004609.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CRELD family.
CC {ECO:0000256|ARBA:ARBA00005897}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005797268.1; XM_005797211.2.
DR AlphaFoldDB; M3ZQW6; -.
DR STRING; 8083.ENSXMAP00000004609; -.
DR Ensembl; ENSXMAT00000004614.2; ENSXMAP00000004609.1; ENSXMAG00000004593.2.
DR GeneID; 102230888; -.
DR KEGG; xma:102230888; -.
DR CTD; 79174; -.
DR eggNOG; KOG4260; Eukaryota.
DR GeneTree; ENSGT00940000160071; -.
DR HOGENOM; CLU_038974_1_0_1; -.
DR InParanoid; M3ZQW6; -.
DR OMA; KCHDISA; -.
DR OrthoDB; 337149at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR021852; DUF3456.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24038:SF13; PROTEIN DISULFIDE-ISOMERASE; 1.
DR PANTHER; PTHR24038; STABILIN; 1.
DR Pfam; PF11938; DUF3456; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00261; FU; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01248; EGF_LAM_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..358
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004047007"
FT DOMAIN 140..182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..334
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 335..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 358 AA; 39453 MW; 0A98C982BD2EE5FB CRC64;
MLSPCLPQLR LISCSILLIL LFQAGDTKRD LKSACSTCQQ ITENFNKGYD RTAKQNFGGG
NTAWEERKLS KYETSEIRLM EILEDLCDSS SFECNRMVEE HEEQFETWWF KKKTKHPDLH
KWFCIDTIKV CCPKGTFGPD CNACLGGSER PCHGNGVCDG DGTRGGNGKC SCDHAYKGEF
CLDCVDGYFN QVRNDTFSLC TECDTSCKTC TGATNQDCDE CKEGWEKDDQ EACVDVNECA
KEPSPCKEDQ YCLNAEGSYS CNGCDEACTG CTGGGPDECQ ACAEGYKDVE GTCTDIDECS
QSEPACVKEN QECVNNKGSF ICICSSGYEE EDGECVQQSD EKEESEASET TPGPHGEL
//
