ID M3ZRI7_XIPMA Unreviewed; 530 AA.
AC M3ZRI7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cell division cycle 73 {ECO:0000313|Ensembl:ENSXMAP00000004830.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004830.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004830.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004830.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC73 family.
CC {ECO:0000256|ARBA:ARBA00010427}.
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DR RefSeq; XP_005802447.1; XM_005802390.2.
DR AlphaFoldDB; M3ZRI7; -.
DR STRING; 8083.ENSXMAP00000004830; -.
DR Ensembl; ENSXMAT00000004835.2; ENSXMAP00000004830.1; ENSXMAG00000004807.2.
DR GeneID; 102227169; -.
DR KEGG; xma:102227169; -.
DR CTD; 79577; -.
DR eggNOG; KOG3786; Eukaryota.
DR GeneTree; ENSGT00390000001114; -.
DR HOGENOM; CLU_025849_0_1_1; -.
DR InParanoid; M3ZRI7; -.
DR OMA; CAFHLKY; -.
DR OrthoDB; 180759at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0034243; P:regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 3.40.50.11990; RNA polymerase II accessory factor, Cdc73 C-terminal domain; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; CDC73 DOMAIN PROTEIN; 1.
DR PANTHER; PTHR12466:SF8; PARAFIBROMIN; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 1..296
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 356..519
FT /note="Cell division control protein 73 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05179"
FT REGION 258..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 60456 MW; 5BDCBB0495BB63C4 CRC64;
MADVLSVLRQ YNIQKKEIVA KGDEVIFGEF SWPKNVKTNY IIWGTGKEGQ PKEYYTLDSI
LFLLNNVHLP HPSYVRRAAT ENIPVVRRPD RKGLLSYLNG ESSTSTSIDR SAPIEIGLQR
ATQVKRAADE VSSEAKKPRI EDAERVRLDK ERLAARLEGH KEGIVQTDQI RSLSEAMSVE
KIAAIKAKIM AKKRSTIKTD LDDDITLKQR SFVDAEVDVT RDIVSRERVW RTRTTILQST
GKNFSKNIFA ILQSVKAREE GRAPEQRPAQ NTTQVDPSLR NKQPVPAAYN RYDQERFKGK
EETEGFKIDT MGTYHGMTLK SVTEGASARK AQTPALQPVP RPVSQARPPP NQKKGSRTPI
IIIPAATTSL ITMLNAKDLL QDLKFTTSED KKKQGIQRDN EVLLQRRKDQ IQPGGATLSV
TVPYRVIDQP LKLAPQDWDR VVAVFVQGPA WQFKGWPWLL PDGSPVDIFA KIRAFHLKYD
EAKTDPNVQK WDVTVLELSR HKRHLDRPVF LRFWETLDRY MVKHKSHLRF
//
