ID M3ZRK8_XIPMA Unreviewed; 1036 AA.
AC M3ZRK8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Mtr4 exosome RNA helicase {ECO:0000313|Ensembl:ENSXMAP00000004851.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004851.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000004851.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004851.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005798698.1; XM_005798641.2.
DR AlphaFoldDB; M3ZRK8; -.
DR STRING; 8083.ENSXMAP00000004851; -.
DR Ensembl; ENSXMAT00000004856.2; ENSXMAP00000004851.1; ENSXMAG00000004799.2.
DR GeneID; 102228439; -.
DR KEGG; xma:102228439; -.
DR CTD; 23517; -.
DR eggNOG; KOG0948; Eukaryota.
DR GeneTree; ENSGT00940000156183; -.
DR HOGENOM; CLU_002902_0_1_1; -.
DR InParanoid; M3ZRK8; -.
DR OMA; IMLKNYN; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 138..294
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 368..572
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 116562 MW; 88966E8FEF76FC10 CRC64;
MADPFGDGLF SVFDDEQQGS AGKKAPTSAS TEIGKSAGKS GTDRDAGPSV RVKREADSDG
GEDVVFEKKP RHEAVSSSDL NLAEFMPQVK VEQVETVEGC SHEVALPSDE EYKPLKPRVG
KAAKEYPFVL DPFQREAILC IDNNQSVLVS AHTSAGKTVC AEYAIALALR EKQRVIFTSP
IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS EIMREVAWVV
FDEIHYMRDA ERGVVWEETI ILLPDNVHYV FLSATIPNAK QFAEWICHLH KQPCHVVYTD
YRPTPLQHYI FPAGGDGLHL VVDENGDFRE DNFNTAMQVL RDAGESGGSS GGGKWDRGRK
GGTKGPSSVF KIVKMIMERN FQPVIIFSFS KKDCEAYALQ VSKLDFNNDD EKRLVEEVFN
NAVDCLSDED KKLPQVEHVL PLLKRGIGIH HGGLLPILKE TIEILFSEGL LKALFATETF
AMGINMPART VLFTSARKFD GKNHRFITSG EYIQMSGRAG RRGMDDRGIV IFMVDEKMSP
AVGKQLLKGS ADPLNSAFHL TYNMVLNLLR VEEINPEYML EKSFYQFQHY RALPGVVEKI
KKLEEQYHTI EIPNEESVIT YFKIRQQLAK LGKEIQEFIH KPKYCLPFLQ PGRLVKVKNE
DTDFGWGVVV NFSKKTNTKV YGDAEPLYVV EVLLHCSKES VKNSATEAAK PAAPGETGEM
QVVPVMLHLL TSISSVRLYI PKDLRPFDNR QLMLKSIQEV QKRFPDGVPL LDPIDDMGIK
DPGLKKVIQK VEAFEHRMYT HTLHSDPNLE SVYSLCERKA QIAAEVRTAK RELKKARTVL
QMDELKCRKR VLRRLGFASP SDVIEMKGRV ACEISSADEL LLTEMVFNGL FNDLTVEQAT
ALLSCFVFQE NANEMPKLTE QLAAPLRQMQ ECAKRIAKVS ADAKLEVDEE TYLNQFKPHL
MDVVFAWANG ATFAQICKMT DVFEGSIIRC MRRLEEVLRQ MCSAAKAIGN TELENKFAEG
ITKIKRDIVF AASLYL
//
