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Database: UniProt
Entry: M3ZS96_XIPMA
LinkDB: M3ZS96_XIPMA
Original site: M3ZS96_XIPMA 
ID   M3ZS96_XIPMA            Unreviewed;      3818 AA.
AC   M3ZS96;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   13-FEB-2019, entry version 38.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSXMAP00000005089};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000005089, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000005089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005089};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000005089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005089};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights
RT   into evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000005089}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005089};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   STRING; 8083.ENSXMAP00000005089; -.
DR   Ensembl; ENSXMAT00000005094; ENSXMAP00000005089; ENSXMAG00000004873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155288; -.
DR   OMA; TKHILKM; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR   GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    201       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      209    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1010   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1340   1552       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      457    477       {ECO:0000256|SAM:Coils}.
FT   COILED     1867   1894       {ECO:0000256|SAM:Coils}.
FT   COILED     2040   2060       {ECO:0000256|SAM:Coils}.
FT   COILED     2881   2901       {ECO:0000256|SAM:Coils}.
FT   COILED     3606   3633       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3818 AA;  431781 MW;  2EA95F3CFAFC6ED9 CRC64;
     RKQALNKGVF VQDDQVVLQC TASVLKEQQI KLCLSCEGFG NRLCFLETTS NAQNVPPDLA
     ICTFILEQSL SVRALVEMLA NTVEMTESSQ GGGHRTLLYG HAILLRHHHS GMYLSCLTTS
     RSLTDKLAFD VGLQEDSIGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY
     ASGDLMVDAS FMQTLWNMNP ISSGCELAEG YLTGGHVLRL FHGHMDECLA IPTPEEGEEK
     RRTAHYEGGA VCSQARSLWR LEPLRISWSG SHMKWGVSFR IRHITTGRYL CLDDDKVLMV
     VDPEKSNTKM SAFCFRISKE KVDVSQKRDV EGMGIPEIKY GESMCFVQHV STGLWLTYAA
     LDAKAARLGT MKRRVILHQE GHMDDALTVS RSQTEESQAA RMIYSTTGLF RQFIKGLDSL
     SGKNKSPGSV SLPLEGVILS LQDLIFYFRP PEEELEHEEK QTKLRSLRNR QNLFQEEGMI
     TIVLECIDRL NVYNTAAHFS EFAGEEAAES WKEIVNLLYE LLASLIRGNR SNCALFCDNL
     DWLVSKLDRL EASSGILEVL YCVLIESPEV LNIIQENHIK SIISLLDKHG RNHKVLDVLR
     SLCVCNGVAV RSNQNLITEN LLPGRDLLLQ TNIVNYATSV RPNIFLGTCE GSTQYKKWYY
     EMIVDYVESF VTAQATHLRV GWAMTEGYSP YPGGGEAWGG NGVGDDLYSY GYDGLHLWSG
     TVARQVASPS AHTLAADDVV SCCLDLSVPS ISFRINGHPV QGMFENFNVD GLFFPVISFS
     AGVKVRFLLG GRHGDFKFMP PPGYAPCYEA LLPRERMRIE PIKEYKHDFD GVRNLLGPTL
     SLTHTSFTPC PVDTVQIVLP PHLERIREKL AENIHELWAV TRIEQGWTYG SFRDDNKKLH
     PCLVDFQSLP EPEKNYNLQM SGETLKTLLA LGCHVGMGDE KAEENLKKIK LPKTYVMTNG
     YKPAPLDLNH VKLTPNQNQL VEKLAENGHN VWARDRVRQG WTYSIVQDIV NKRNPRLVPY
     NLLDERTKKT NRDSVNNAVR TLIGYGYNIE PPDQESSKLV HLNTRGDKVR IFRAEKSYAV
     TQGKWYFEFE AVTTGEMRVG WARPCVRSDT ELGADELAYV FNGNKAQRWH VGNEPFGRQW
     LSGDVVGCMI DLNEMNIMFT LNGEMLISDS GSEMAFKDIE IGEGFIPVCA LGLSQVGRIN
     LGQNVSSLRY FAICGLQEGF EPFAINMKRD ITMWFSKSLP QFVPVPTDHH HIEVSRVDGT
     VDSAPCLKLT HKTFGSQNAN TDMMFLRLSM PVQFHETFKV PAGTTPLTRA LTIPEEEVVV
     VEPDSEFEVL KKSASRKEQE DEKKEPSVPK EVSVENEKDT MSEKGKKKGF FSKAKKAAMT
     PLAPPPAPPT VPRLVEDVVP DDRDDPEIIL STTTYYYSVR IYAGQEPSCV WIGWVTPDYH
     QYDPTFDLSK VRNVTVTVGD DKGNIHDSMK HSNCYMVWGG DLVSNQQTRF SQEDMVIGCL
     VDLATGLMTF TANGKEINTF YQVEPNTKLF PAVFIQPTNQ NMAQLDLSLL FQNIMPISAA
     MFRSERMNPV PQCPPRLDVQ MLTPVIWSRM PNNFLKPEVG KVGERLGWSV ECVEPLIMMA
     LHIPEENRSE NGCIDILELS ERLDLMKFHY HTLMLYCAVC ALGNNRVAHA LCSHVDESQL
     FYATENTYLP GPLRSGYYDL LISIHLESAK RARLGTNREF IIPMTEETLS IKLYPDVKKA
     HSLPGVGLTT CLRPKLHFSS VNFVGTNPDI YTLSPVFPLQ ELKTRAISMV TEAVLDGSQA
     MRDPVGGSVE FHFVPILKLI STLLIMGIFN DEDTKHILKM IDPSVFSGKE EEEGENAEEG
     EAAEGERGKV DGEKAEEEKE KEAVEAEAKE EEGAPEEGLL QMKLPESVKL QMCTLLQYFC
     DCELRHRVET IVAYSDNFVQ DVQKNQRVRY NQLMRAFTMS AAETARKTRE FRSPPQDQVI
     LLTNFKHGPE DEDCPVPEDV RETLVYFHND ILLHCGIHIE HEAQEEEVDT SLRGRLLSLV
     EKVKNFRKKE EEEVPEVEEE PKPSTLQELI SHTMIHWAQE SFIQNPELVR LMFSLLHRMY
     DGLGELIRAL PKAYAINAVS VQDTMDLLEC LGQIRSLLIV QMGPEEERLM IQSIGNIMNN
     KVFYQHPNLM RALGMHETVM EVMVNVLGGG GDSKEIRFPQ MVTNCCRFLC YFCRISRQNQ
     RSMFDHLNYL LQNSGIGLGM RGSTPLDVAA ASCIDNNELA LALQEQDLEM VVTYLAGCGL
     QSCPMLLSKG YPDIGWNPCG GERYLDFLRF AVFVNGESVE ENANVVVRLL IRRPECFGPA
     LRGEGGNGLL AAMEEAIKIS EDPARDGPTV KKDRRFMFGG EGQHEENRVH LGNAIMSFYS
     ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLPVQIP AYGKEPKMSA
     SFVPDHKASM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTVAFS TTEMALALNR
     YLCSAVLPLL TKCAPLFAGT DHRAIMIDSM LHTIYRLSRG RALTKAQRDV IEECLMSLCK
     YLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA NFGVTSEEEL
     HLSRKLFWGI FESLAHKKFD AELFKIAMPC LCAIAGAIPP DYVDATYSSH TEKKASVDAE
     GNFDPKPVET TNTIIPERLD AFINKYAEHT HDKWAFEKIQ NNWTYGEVLD ENAKTHPMLR
     PYKTFSEKDK EIYRWPIKES IKAMLAWEWT LEKARDGEGE VEKASTRKIS QTAQATYDPS
     HGYNPQPIDI SGMALSRELQ SMAEQLAENY HNTWGRKKKL ELQAKGGGTH PLLVPYDTLT
     AKEKARDREK AQDLLKFLQL NGYAVTRGLK DMEQDISSIE KRFAYGFLQK LLKWMDIAQE
     FIAHLEAVVS SGRVEKSPHE QEIKFFAKIL LPLVNQYFKN HCLYFLSTPA KVLGSGGHSS
     NKEKEMIASI FCKLAALVRH RVSLFGTDAP AVVNCLHILS QSLDARTVMK SGPEIVKAIL
     RQFFESAADD IEKMVENLKL GKVSSKTQVK GVSQNISYTT NALLPVLTSL FGHIAQHQFG
     DDVILDDLQI SCYRLMCSIY SLGTVKTPHV EKQRPALGEC LAHLAAAMPV AFLEPALNEF
     NSFSVYTTKT PRERTILGLP SQVEELCTDI PELDVLMKEI HDLSESGARY TEMPHVIEVT
     LPMLCNYLPR WWERGLENFP EQEGQLCTAV TSEQLNQLLG SIMKIVVNNL GIDEASWMKR
     LAVFAQPIVS RAKPEMLKSH FIPTMEKLKK RAGKVVAEEE HLRMEGKTEV DSENGTIRDE
     FAVLCRDLYA LYPLLIRYVD NNRSESRISA VWSLKLLKLH LLPYFSYITT HFFLVVRSLT
     CRSFQSGGSE QERSKKKRRG DRYSVQTSLI VAALKKMLPI GLNMCSPADQ ELINLAKIRY
     SLKDTDEEVR EFLQNNLHLQ GKVEDPAMRW QMALYKEMSG KAEDAEDPEK VVKRVQEVSA
     VLYHIEVTEH PYKSKKMVWH KLLSKQRRRA VVACFRMTPL YNIPTHRAIN MFLNAYKRNW
     LETEGYSFED KMIDDLSKAL EEEEEEEEET ETKPDPLHQL ILHFSRTALT EKLKLEVDHL
     YMSYADIMAK SCHIGEEDEG GEQEGEEPSF EVRQTEMEME KQRLLYQQSR LHNRGAAEMV
     LQMISACKGE PGAMVSSTLK LGISILNGGN SDVQQKMLDY LKDKKDVGFF LSVQALMQTC
     RSVWILHLVK VMADDEFTCD LFRFLQLLCE GHNNGKNN
//
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