ID M3ZSI3_XIPMA Unreviewed; 2650 AA.
AC M3ZSI3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000005176.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000005176.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005176.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 8083.ENSXMAP00000005176; -.
DR Ensembl; ENSXMAT00000005181.2; ENSXMAP00000005176.2; ENSXMAG00000005119.2.
DR eggNOG; KOG1020; Eukaryota.
DR GeneTree; ENSGT00390000010427; -.
DR HOGENOM; CLU_000763_0_0_1; -.
DR InParanoid; M3ZSI3; -.
DR OMA; LYIQMVS; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 2247..2427
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 341..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2448..2478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2592..2650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2604..2626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2650 AA; 302901 MW; 916C7B4CB46589C4 CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTAKSL LYNGRISDEV SSLLVCRDEN
LVTQLAHSLN QVSTEHIELK DNLGNDEPEG DMPILLQTLL TRNPRIFRDK SMLTFASVLQ
QPLIQQYKIS QNQVHGSPAS NYQQSPSGCF TSPQCGSATQ FVPQQNSPIP SPYTPQSPAD
YIQYNPPSYS HQTQQVVSGA RTILDNKISE HLSSNSSNRN SKPSLDEDYV NVAQRLGNEV
MLGIRPRPPL IMQSPPLEAG TAPDLLLTTA DRKKKQRERN KEENENMDKN VFYDIVSSPS
KDSARLTLKL SRVKIPDTGR SEELLPTSPT DSDHNAVVLN NDIQSSGSPQ DFSHKSVVEE
HQQDAAQPIT KETGVISGIV FDDSEIDAFA EIERIDSANE RERCSKEVQD KDKPLKKRKQ
DTYPQEPGVE TNEGPSLHGG SNVSRLTPKK SSAASNGASR PALMVSIDLK QAGRVIGQPV
VVLEQQPLCD DHIRRLKTSA DTENRPGIIK KLPDTCQMHI SDGHTESNKQ KQNNQRESKR
NHDSKLDCDK GHSEDRHVEM TRLKQDRHSD FRHKEEKNNS SHRSQVSRPE TLKSTSKVDR
NSKHEEQKGK NKDKDKERDR QRDKDGDKEK LRDKEISRER DKDKVRDRER NRERDKSIDV
AREEDKYQDK VKSKLRDGDK FRDGEEPIER EKFREEDKSR ERAKDEDKDL EKLKQKLRDR
DKDGEKVRER DKSIDLDKDE DQDVERVKDK VRDKDKIRDK EKKRERDKFR ERDKDQERVK
DNHRENVRGR DKSIDVVKDG DEDVDRIKDK VKDKNRDREK TGGKEKSREI DKDREKDRDK
NRNRDKDENF EVGKEQNKDG KRDRERDKGK DRDRNRDRDR ERDREKNKKH KTLPEGDGNR
ISFEEQTKAE NSKLKQDEGR KSAELNDRQR TSSSSLQTTP NKDQRASGDS NMNQAANKRQ
ACEMKMSEFP PFLLGGNSGS LKNFVIPKLK RDGKEGTDKD LRLKGKLIDG WTEPLVRLER
VSLVKNLNKK TKPVIVVKRL SIEDVKRIIK ETKNAHSSRS RHWASFDKSD RECEKDLILI
SVSIGVSAPR KRKKKDHDKS WKFEEKKGSR DHRRSGGFQN SRRGSSGRHR DWSCNDDSDG
DSPPPSLNDV ARKIKKQKSK MAYNSKMTTE EKMDSSAFKR FANSVDNILE SLEDVDLTAE
DDEIPQELLL GKQQLNELGS DSTKIKAMGV FNKFSSSKLV KILNMLEKNI QDSVTLSTLM
SQDNDSMDEE RLWRDLIMER VIKSADACLT ALNIMTSPHM PKAVYIEDVI ERVLQFTKFH
LQNTLYPQYD RSYRADRHGG ASHTSKSKRP KSSAHKQKVV VGLYNKVCDI ISVISELLEI
QLLTDTTILQ VSNLGITPFF VENVNELQLC AISVVTAVFS RYEKHRQLIL EEIFASLARL
PTSKRGLRNF RLNTSDSGGP PLYIQMVSAL VLQLIQCVVN LPNERETEEE PKKKVDKDIL
ITNSYEIAMR TAQNFLSVFL KKCGSKQGED DYRPLFENFV HDLLSAVNKP EWPAAELLLS
LLGRLLVHQF SNKQTEMALR VASLDYLGTV ASNLRKDSLS CKMDQRTIDR ILKETPGSDE
VQQLQKALLN FLDENIDADP ALLFARKFYI AQWYRDTTVE VEKAMKSQND DDDPKYRRHS
MDSDATGEIV QTVEARKKFL RKIIKTTPSN FSSVKISSDT VDYEDSCLIV RYLASMRPFA
QSFDIYLSQI LRVLGESAIA VRTKAMKCLS EVVAVDPSIL GRVDMQRGVH CRLMDNSTSV
REAAVELLGR FVLSRPELIE QYYDMLIERI LDTGISVRKR VIKILRDICL ELPDFHKITE
MCVRMIRRVN DEEGIKKLVN ETFQKLWFSP TPSHDEEAMN RKILNITDVV RTTFLVLKIE
NISFLLLLKS EEDASYKPTK KACVQLVDNL VEHILKYEES IADCEEKGIN SGRVVACITT
LFLVTKIRPI LMVKHAMAMQ PYLNTKCNTQ NDFMVICNVS KILELVVPLM ENPSESFLNT
IEGDLMKLII KHGMTVVQHC VSCLGAIVNK VTHNYKFVWA CFNRFYGALA KLKTQHQEDP
SSSTLAANKP TLLRSLFTVG ALCRHFDFDQ EEFKGANKII IKDKVLELLL YFTTHEDEEV
QIKAIIGLGF QFIMHPELMF AQDVKVLYIS LLSEENRAVN LKIHVLKNLQ TYLQEEDSRM
QEADREWNKQ AKQEDLKEMG DISSGMSSSI MQIYLKQVLE SFFHSQSTVR HFALNVITLT
LSQGLIHPVQ CVPYLVAMGT DPEPTMKNKA DQQLVEIDKK YSGFIHMKAV AGLKMSYQVQ
QAINGGKRAA VRGFRHDDSD SALCSHLYSM VRGNRQHRRA FLISLLNLFD DSSKTEVNML
LFIADNLACF PYQTQEEPLF IMHHIDITLS VSGSNLLQSF KEVRVFKRKK NSSSDEEEEE
VRKRKKPGGG DSDSDLGDEE AVMDRLPENT TPLQEFASAS QGILLLLVLK QHLKNLYGFS
DSKIQKYSPT ESAKVYDKAV NRKSKVHFNP RQTLEYLRSD VANRNLSYET KRNIVKQFLD
FKVLMEHLDR DEEDEDGGEA NANARNKAIN SLLKGPKPQN HNHSNHTAPV ETDDEESEDE
DPPAVRMTIP
//
