ID M3ZU36_XIPMA Unreviewed; 1201 AA.
AC M3ZU36;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSXMAP00000005729.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000005729.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000005729.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000005729.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M3ZU36; -.
DR Ensembl; ENSXMAT00000005735.2; ENSXMAP00000005729.1; ENSXMAG00000005703.2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000156235; -.
DR HOGENOM; CLU_003982_1_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 812..934
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 964..1188
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 21..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 133610 MW; 35F66EC3F2B255C9 CRC64;
MSRKIESKQD SQRSHLSTFT MILKDKFHSP KIKRTPSKKA KQLQPEPAAK STEKPANKKV
SRLEEHEKEV VSALKYFKTI VDKMVVEKKV LEMLPGSASK VLEAILPLVQ VEARIQHSSA
LSSCHSRVYQ SLGNLIRWAD QVMLDGIDLD DKESVIAVTS VIKAVLDGVK ELVKLTIEKQ
EQPSPTTPNK PAPPVTTAES NVSVEVPLID SEQEVSKRTA PATSPAKAAP QLQDEDVAPP
KPPLPEAKVA ELRAQLSADA GQRRPSSQKE NPPPALPPKK RQSAPSPTPV AVVAPMSRGS
SLPCSDHRQE YEQEFFQRRF SGGSHSYGGD SPRLSPCSSM GKLSKSDEQL SSMDQDSGQC
SRNTSCETLD NTESYDPDYD FLHQDLSAGD NLPAVQAGGC LSPLPESHSE SSSPVPGQHL
THPPLSAPPS QQPEYWTPQP NHSNPIQPCR TSAPPALPLK KRRSTQTSSF SDGGSRVLYE
RYPSQYDNLS EEELHPTPPF PLFTPISPMP QTNGGVFVSQ FMTSENADVP TNPPPLPEKK
NRHILQYMQF MEDYSEPQPS VFYQMPQSER IYEQHNKLFQ EVYGFNDSFS STDSVHEPLQ
PPALPPKQRQ LASHSSSPSS SSSSSLSCHL QPSVAALEEA GSGLGLSMSV SNSYLIGQAS
LTTPTSLDQV ALTNATVLDG SGGGPNGSLA GSMGSVAVCL PSESSLTDSL HTSASESVND
EGGEGEYVNL YSSSQANGEL PLSLRETIAA DDVLQDPVPQ MPSSNSKEAL DKERRQKTAE
KAGSVEEDVD ELSLIDHKEI MSRITLKQEN DDGPDVRAGS GDILLVHATE TERKDLVLYC
EAFLTTYRTF ITPEDLIKKL HYRYTTFCHS PDTFKKRVSK NTFFVLVRVV DELCLVELTE
DILKQLMDLV FTLVCNGELS LARVLRKNIL DKVEQKKLLR YTNSLKPLAA RGVSARPGTL
HDFRSHEIAD QLTLLDAELF YKIEIPEVLL WAKEQNEEKS PNLTQFTEHF NNMSYWVRSL
IIQQEKAQDR EKLLLKFIKI MKHLRKLNNF NSYLAILSAL DSAPIRRLEW QKQTSEGLEE
YCTLIDSSSS FRAYRAALAE VEPPCIPYLG LILQDLTFVH LGNPDLIDGK VNFSKRWQQF
NILDSMRRFQ QVHYELKRNE EIISFFNDFS DHLAEEALWE LSLKIKPRNI SRAKTDRGEK
T
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