ID M3ZV14_XIPMA Unreviewed; 1310 AA.
AC M3ZV14;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Contactin-associated protein-like 4 {ECO:0000313|Ensembl:ENSXMAP00000006057.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000006057.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000006057.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000006057.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014330289.1; XM_014474803.1.
DR STRING; 8083.ENSXMAP00000006057; -.
DR Ensembl; ENSXMAT00000006063.2; ENSXMAP00000006057.1; ENSXMAG00000006010.2.
DR GeneID; 102224048; -.
DR KEGG; xma:102224048; -.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000160228; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; M3ZV14; -.
DR OMA; HISDRSG; -.
DR OrthoDB; 4255614at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF40; CONTACTIN-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1310
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004046989"
FT TRANSMEM 1242..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..177
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 183..362
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 368..544
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 546..583
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 582..634
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 793..958
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 959..997
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1015..1203
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1278..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 931..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1310 AA; 144073 MW; 6EEBF8FD3AC8C4E1 CRC64;
MESKRVAGII PRVARLLLLL GLFGTTAEEE CDSPLVSNLL PSSFRSSSQL SSSHAPGFAK
LNRRDGAGGW SPLTSDRHQW LEVNLGERTK ITAVATQGRY GSSDWLTSYQ LMFSDTGHNW
KQYRQEDSIG SFPGNSNADS VVQYKLQQPV VARFLRLIPL DWNPNGRIGL RLETYGCPYT
SDVVTLDGSS SLVYRLNPGS RRAQRDVIAL KLKTLRNSGM LLQAEGREGL GLRLELDRGK
LLLLFRQGRT LSAEPQRLAA LGSLLDDQHW HHVAVELHGL HLNLTVDKHT LRVKIPPQFH
HLDIQELSVG AVQALGSHKP FHSKRNFHGC LENLLFNGLN LIELAKVKDH KVSLVGNVTF
SCAEPVPVAV TFPGLQSFLQ LPWTTPLSSG SMSIGFQFRT WNKAGLLLTF ELPQQGGVAW
LFLSEAKLRL QIQKGGRVLL ELSAGSALSD GQWHSVALTS GRSHLSVCVD KDEGGSAQAS
LSFPVAVESH VFFGGCPAGD APGCRNHFTS FQGCMRLLSL DGSIMDLIAV QQLGNYSNLQ
IDMCGIIDRC SLSRCEHGGY CSQTWTVFHC NCSDSGYSGA TCHSSVYEQS CEAYKHSGNT
SGYFYIDVDG SGPIKPQLVY CNMTESDTWM IIQHNNTELT RLRPVSGVDQ QSLHFSYSSE
EEQLLGSIGQ SEHCEQELSY HCRKSRLLNT PEGSPFSWWL GGRAPGREQT YWGGAHPGSQ
QCGCGLRGDC VDPQHYCNCD ADRLEWTEDS GLVTHKESLP VRSLVLGDLQ RPGSEAAYSV
GPLRCYGDKN FWNAAFFDKE TSYLHFPTFH GELSADISFF FKTTSSSGVF LENLGIKDFI
RIELSTSARV VFSFDVGNGP LEVKVESTVP LNDNRWHRVR AERNIKEASL RLDDLPVATQ
EAPADGHVHL QLNSQLFIGG TASRQRGFRG CIRALQLNGV TLDLEERAEM TPGVRPGCPG
HCSSYGSLCQ NQGRCVERAA GFHCDCSLSA YTGVFCQTEL SAGFKPGTSV RYTFKEPYEL
TRNSSALPSS IYSDTTLRGE NVSMSFRTAQ SPALLLYVGS YYREYMAVLI NKHDKLEVRY
KLEGNRDAEV LRSSSARNLA NGQLHSVTIR RLTHTVSVQV DQNAREDFNL TSDGEFNAIK
SLVLGKVHES GDLDSHLARL ASLGFTGCLS VVQFNSINPL KAALLHPDTS PIIITGPLVR
SNCGSAASAN PYAAENIHHI SDRSGSVGSG QPLVNAIRTD SALIGGIIAI VIFVVLTGLA
VAARYLYRRK DTYRNQEGNA VKQEDSPDFP FNNQTDSQNL SSENPKEYFI
//
