ID M3ZVJ8_XIPMA Unreviewed; 1709 AA.
AC M3ZVJ8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIN2B {ECO:0000313|Ensembl:ENSXMAP00000006242.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000006242.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000006242.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000006242.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. NR2B/GRIN2B subfamily. {ECO:0000256|ARBA:ARBA00038189}.
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DR RefSeq; XP_005810957.1; XM_005810900.1.
DR RefSeq; XP_005810958.1; XM_005810901.2.
DR STRING; 8083.ENSXMAP00000006242; -.
DR Ensembl; ENSXMAT00000006249.2; ENSXMAP00000006242.1; ENSXMAG00000006209.2.
DR GeneID; 102219598; -.
DR KEGG; xma:102219598; -.
DR CTD; 110438919; -.
DR eggNOG; KOG1053; Eukaryota.
DR GeneTree; ENSGT00940000155964; -.
DR HOGENOM; CLU_002598_0_0_1; -.
DR InParanoid; M3ZVJ8; -.
DR OMA; KNDRYSG; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06378; PBP1_iGluR_NMDA_NR2; 1.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF382; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 647..669
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 719..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 837..854
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 910..933
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 520..888
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 531..592
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 1075..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1709 AA; 187788 MW; 366135D143A1A7C3 CRC64;
MRLWLAKHEV FLSHSYIMPL RGRCSSSLPH QHAGAHFSPR MVAQVQHGAR TLHPPPPPSV
HRTTGTSLCL PLLFLLLCLL HLPPACHSRR EKGGGGGGGH YMPIPQPPPH HMALPNILRG
LSIAVVLVGN SSEVALAGAR EKEDFLHIAP NVEVLTMNET DPKSIIKSIC DLMTEHWLQG
VVFGDDTDQE AIAQILDFIS AQTHIPILGV RGGSSMIMAA KDDNSMFFQF GPSIEQQASV
ILNIMEEYDW YIFSIVTTYY PGYQDFVTKI RNTIENSFVG WELEEVLLLD MSVDDGDSKI
QNQLKKLQSP VILLYCTKEE ANTIFEVAHS VGITGYGYTW IVPSLVAGDT VVVPAEFPTG
LLSVSYDEWD YGLEARVRDG VAIITMATST MMMDRGPHTL LKSECHGAPE KKTPISGNPN
EVLRYLMNVT FEGRNLSFSE DGYQMHPKLV IILLNKERQW DRVGKWENGS LSMKYHVWPR
YELYGGAATR EDDHLSIVTL EEAPFVIVED VDPLSGTCMR NTVPCRKQIK TLNQTKESGI
YIKRCCKGFC IDILKKIAKS VKFTYDLYLV TNGKHGKKIN GTWNGMVGEV VLKNAHMAVG
SLTINEERSE VIDFSVPFIE TGISVMVSRS NGTVSPSAFL EPFSADVWVM MFVMLLLVSA
VAVFVFEYIS PVGYNRCLAD GREPHGPSFT IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM
VSVWAFFAVI FLASYTANLA AFMIQEEYVD QVTGLSDKKF QSPNKFSPPF RFGTVPNGST
ERNIRNNYPE MHTYMTAFHQ RNVNEALQSL KAGKLDAFIY DAAVLNYMAG RDEGCKLVTI
GSGYIFATTG YGIAIQKESG WKRHVDLAIL QLFGDGEMEE LESLWLTGIC HHEKNEVMSS
QLDVDNMAGV FYMLGAAMAL SLITFICEHW FYWQLRFCFM GVCSGQPGFV FSVSRGIYSC
IHGVQIEEKS SSALNSPSAT MNNTHSNIMR LLRTAKNMAS LSGVNGSPHS ALDFIRRDSS
VYDISEHRRS LAGHSDCKPP YMPEDNMFSD YISEVERTFG NLHLKDSNLY QDHYLHHHGS
TPGLTGPPPN RPHSLGSASS LEGGMFDCDS LGGGVAPIFT TQPCSALTHR NMSKFDLLSG
QTPPSGQSFK GGLPDVYGKF SFKGGASSST YIPGPSYCGG RGDDDGNIRS DVSDISTHTV
TYGNLEGNAK KRKQYRDSLK KRPASAKSRR ELDEIELGYR RKPYHISHHH YHSQRSVSPP
LLPSERKRGG GGGNNNGNSY LFREKESVRD FYLDQFRPKE GVPQWEHVDL TEGPGNRDGG
VPTCTSLVPV EDFLKSKPKK SDSKGGPGSG LAGGEWECRN CRASGGKQIS IHGGGGGYSS
GMGCGSSAGG SRPSSATCMR CEGCKKTGNL YDISEDNNHP LEQMGGGKGG GGVGCMAAGP
QAQSQAQQRR KSGGFGKQLR RQHSYDTFVD LQKEESGGMG SLMGGLGGGM GGPGMGGMLP
PPRSVSLKEK ERYMEENSPF AHIFERHGGS ERERERDRDP LFYGGESQKG SGSPFGLFRG
GEGLHRRSIG ERDMRDRSLM EGGGGAAFSL SKSLYPDRVN QNPFIPTFGD DQCLMHGAKQ
YYLTKQQQQQ QQVAQNSRGD FRSQLSATSY LPASATAGVM PNVPPRFPKE LSLGGMNHHG
SMLAVGPPRP FNGSNGHVYE KLSSIESDV
//
