ID M3ZVX5_XIPMA Unreviewed; 1386 AA.
AC M3ZVX5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Partitioning defective 3 homolog {ECO:0000313|Ensembl:ENSXMAP00000006369.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000006369.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000006369.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000006369.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR STRING; 8083.ENSXMAP00000006369; -.
DR Ensembl; ENSXMAT00000006377.2; ENSXMAP00000006369.2; ENSXMAG00000006330.2.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_0_0_1; -.
DR InParanoid; M3ZVX5; -.
DR OMA; EPRGHHA; -.
DR OrthoDB; 5405986at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 279..355
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 465..539
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 593..668
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 154239 MW; 3D3A6CC4FB70D15B CRC64;
MKVTVCFGRT RVVVPCGDGN IKVHALIQQA VMRYKKAIAK DANYWLQVHR LEHGDGGILD
LDDVLCDVAD DKDRLIAVYD EQEPHHGGDG TSASSTGTQS PDLFAADLGA GSVASAFQPY
QNASEIEVTP SALRANMPLH VRRSSDPALI TINGPFSASE LRVQTEEPPS RKNPTRWSTT
AGFLKARHSS GTNSLERKSK GLDTYRSLPR DAGTWSNQRE FQRDTARSSL SANHPMVDRW
LEKQEQEEES REDENGRIEP VGRADSCMEH TPVRSLEDIV KLVEVSNDGG PLGIHVVPFS
GRDRRTLGLL VKRLERGGKA EHQGLFQEND CIIRINNGDL RNIRFEQAQN MFRQAMRSPV
IMFHVVPSSM KAHYEQLSHT ERNPSFSSGR FSPDSLSGID HNPQRINRHG SQTQTHPDPN
NGYPHLTHPA VTAAKPPTGH THSPQRGLNS TPTPGYTKKV GRRFNIQLKK GPEGLGFSIT
SRDVPIGGSA PIYVKNILPR GAAIQDGCLK AGDRLLEVNG VDLNGRTQEE VVSLLRNTPM
GGAVGLLVLR QEDSFPPREV SAEPQKQSHR DLKTEEDELV LTPDGTREFL TFEIPLSDSG
SAGLGVSVKG NRSKENHADL GIFVKSIING GAACKDGRLR VNDQLIAVNG ESLLGKTNQD
AMETLRKSMS TEGNKRGMIQ LIVARRVAKR NEDSSGNPLG SQQTVNTSLD DHERRISHSL
YGGLEGLDDD LMPRQGMIPR TIGNYQLSPT VNMPQDDTVI IEDDRPPLLP SNMSDQSSSS
SHDDVGFVAD VTPPWAKELP AHNESALSPD ENNPDVSFQR EGFGRQSMSE KRTKQFGDAA
QLEIIKTRKS KSMDLVADEI NLTPRPDTDA GSSTKDVGPS LGLKKSSSLE SLQTAVAEVT
LNGDLPFHRP RPRIIRGRGC NESFRAAIDK SYDRPAALED DDEGMETLEE DTEESSRSGR
DSVSTMADQT PLSAGPEKPL VNGTNRTKEE KKKDKDKPGK EKKKQDGGKE KDKEKGKPKK
GMLKGLGDMF RFGKYRKDER PAEKMDRKGS SKWRTEETQV SDEETMKMRM EQERIQAKTR
ELRERQARER DYAEILDVSR PLDRSSEEDH TYSGVNPLNM DSSHSRAHSP RDEYSHVHHQ
HQHSDSLYSP VSRARNDRPP STDSNRLTPS NHDRIQRLRQ EFQQAQNVPD DPDDRRRTYS
FEQSWSNSSS NGPGGYSQPG RHSVSVEVQM QRQRQEERDS FAQAQRQYSS LPRQPRKNPS
TVSQDSWDKA YPPGDVFQTA KDNPRYSSYQ GSRNGYQGGG GGTGVNARVL LEAQELLRQE
QRRREQEAKG KMLQEGSRTS AYEGYIPHLK EPGSPKGPYR HDVPPSPSQL ARLNRLGSEK
GRLFYS
//
