ID M3ZW56_XIPMA Unreviewed; 1139 AA.
AC M3ZW56;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000006450.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000006450.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000006450.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000006450.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005803592.2; XM_005803535.2.
DR AlphaFoldDB; M3ZW56; -.
DR Ensembl; ENSXMAT00000006458.2; ENSXMAP00000006450.1; ENSXMAG00000006436.2.
DR GeneID; 102220797; -.
DR KEGG; xma:102220797; -.
DR eggNOG; KOG1117; Eukaryota.
DR GeneTree; ENSGT00940000157424; -.
DR HOGENOM; CLU_008887_0_0_1; -.
DR InParanoid; M3ZW56; -.
DR OMA; NEVQEGW; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899:SF5; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 432..521
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 527..651
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 934..1139
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 124710 MW; 0521CA1220EBD4A7 CRC64;
MALPPSPPVP KPRLHSSKSV PSVLNRNSAH ELQLSFPRGR HQSTDEDALP LSSPRKSTRD
NFPTLDGITD LIAANIPSLA GVATSFSASA PSAPPPIDSL TDSISTTIPG LAEAANAVAA
NGEATLRPAP STPAANSSDS PSLESIISSL SNITSLEEFV NNIPNPSAPP LSLEPHPPLN
MNGGSHTDVG ALSQLVKASL DPTAGVKFPS MEVAGVTAQE VQSPSPLSIK EEDPYVTVLG
TWTNQEEAES ESSNEEDDKG SSPAVSGSEA SVDKDPGSDP VTTRVSPNQS DRLKPTRPAP
PPPSRKSKPV KQKIPRAATI RVSRKKGGGG GSAPQSAVVR ASWLDVWKGF RYSVLWVTLD
GQLMSLRKKR TDRFSELLFH VSSITNVKPQ DKRRFSVYFR KKHYDFMAHS NEVQEGWVTS
LLATRGLQSP TPSELHGQVT LKDSRSRAYA AVWGHDLWIY PNKDSFQLGI ASFSVPLNVA
TVKATGKHSF ALVTPYKTFN LSVDSSKDLS LWLDSLTSTI QSAESCSQVA LRLWENPYNK
VCGDCGAANP EWASVNLLLV ICHNCAAQHR VLGNSLSRVR SLRMDNKTWT EPLIQLFVTY
GNRLANQVWA PAVPAADQLH PEATEQERAA FIQNKYSRGR YRRVHALTSS RSMMNQRLCQ
VVVSDNVEET MSLICSGAKV SSSDPQSPSP ILLAEKASQA LQIELLRLNE YTEVRPHQPQ
PANRKQASVP SGEEEEEEEE LHGKLEADRF FFSLENDSAA CDVLDLREVL SVFLKDGSAL
QFEMVTLNDH IICDADNSDS LQNHLVHILK VILPGGVSYA EVGGASAVSK VRMVDVGGAS
TQSDAWLVLW DEGVSLHPVE RAGQRSLTFP LSMLSPTDMV LYEDTITLVT AERTVSLRFE
EQRSTETMFQ HLKRALANQH PASEGPPAAN QNPARLSQMS MTDGAVKGSV SPAIQRCVSH
ITTYGLKVEG LYRRCGLALK VKELVKALMT SPNSAPLEAH EQGILDVGSS LKQIIRDQQS
LVPQAELQQW QKAAVIPKER SRFKEYRRLL RQLPPDSRAT LNMMFGHLYM VQVFSQDNKM
SAHNLAVVLA PSMFQVMSQD MIALTREFII HHTLLFLTPD RKDEDKAEED DEEEQITLL
//
