ID M3ZYU7_XIPMA Unreviewed; 1803 AA.
AC M3ZYU7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007391.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007391.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007391.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR STRING; 8083.ENSXMAP00000007391; -.
DR Ensembl; ENSXMAT00000007399.2; ENSXMAP00000007391.2; ENSXMAG00000007367.2.
DR eggNOG; KOG2633; Eukaryota.
DR GeneTree; ENSGT00940000154311; -.
DR HOGENOM; CLU_012160_2_0_1; -.
DR InParanoid; M3ZYU7; -.
DR OMA; QQFNCLI; -.
DR OrthoDB; 5471082at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR CDD; cd02907; Macro_Af1521_BAL-like; 1.
DR CDD; cd02903; Macro_BAL-like; 1.
DR CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 3.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR14453; PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14453:SF88; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR Pfam; PF01661; Macro; 3.
DR Pfam; PF00644; PARP; 1.
DR SMART; SM00506; A1pp; 3.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52949; Macro domain-like; 3.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS51154; MACRO; 3.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50918; WWE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 779..966
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 996..1181
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 1209..1383
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 1527..1605
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 1612..1803
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT REGION 83..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1501..1535
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1803 AA; 199187 MW; D9C1E9FACFD07106 CRC64;
MAEEYAFHVL VELEESNTPR LKNKLVKYFQ SKKSNGGDCE VDYESGSSTA LLRFRREEDQ
KNVLGKESHQ ISLDKGVLKM AVRLPSDGKQ KRGDSTDKGS KKSDHEGTNK QSKVQEPKPV
DEGQTGAKGK DGDSDDEEQC SKSAVLGNIP DSLTSEFLEM IVENILRDIS SPTASQDYNL
ELIPDISSAV VTFQSGKDAT DFIERCPQNR MFTKKELSVR PLETTKKVMV EGVSDCSEDM
LCLYFESKGG DVEDVQLNEA EQSAVIIFKN HQDVKKVLGK KHEIKKEEIK VYPFYKSLGV
ALYGKDKPSP KLPAAISEPI DNAVLRYLAN HKAALETVGC DLERHFCNIT LEQSAVRLSA
SPSLLKQKDA KVIIKEWANT VKAAFSQAVS KFKTLKFSLE SDVWEESEQK IKEKLRKEDV
VVVSDKTSGV LSVAGLENDV NTLKKPISDV LDRIEKRVRR EKLSKTQEIN VSPSMFHILS
QDGLQDKLLQ VYPELKMSYD QNKQALKVTG FVDEIINATQ VISNATLGLK RQNLEVDEFL
LDMLKDEQQE EATDILLTAY GIKAALEISP QRVQLVAVSD KDLMNAQDHL SQILKSEYVE
VEDFEVLKKP EWQQLVHQQE KANSGSGMRV QIITHQQQVV VSGHKDSVDK VSSELEDFIT
ENAHVEEFVA VKANVIIEYL KGQTTLLKQL EGVEVSFGNQ EIILSGCRSA VKDCKTIVKA
LLASVCFDSF KVTKPGVKKC FQEKELFFAS SIKSDTDCLV QLADKSNEED DLALVQVQQP
IYKVQTSDGV EIVVSKADMC SYSVDAVVNP STEDLKHTSG LALALSKAAG PQLQTECDQI
IFVKGKLRPG DCVVTDAGGM LRCKKVIHAV GPYFDQAKPK KAEAQLKRTV KESLELAEKC
GCVSVALPAI SRNLGFPLNL CLATIARAVK EYCDEKYDDN TLKKIHLVDN EDSVALGMES
AVKQEFGNHG VSVSSQNAIP KVSQKSSLLK LVPPDPSLCR GQTKEGLNIV LKKGNIEAAK
TEVIVNTVTE DLVLDRGAIS KAIFSAAGPK LQQLVHSQKT KGSPGEIVVT DNCKLKSKQV
FHAIAPHWNN GQGAAEKTLA GIFKDCLDLA EKTRLSSITF PAVGTGNLGF PKNLVATLML
DKFLEFSSQR QSNNLKKIAV VLYPGDAQTI KVFTDEFQKK FPSATGSSAA AGPASADSSK
GKFSKVVSSS GTHETKLGNV TIQVVTGDIT KETTDVIVNS SNDNFTLKSG VSKAILDAAG
VVVFEECQHL GSQPNPGIIM TVPGNLKCKK ILHLVGQTDP VKIHSTVKEA LQMCVKNSYT
SVSFPAIGTG QGNVQAKQVA DSMLDAVIDV FSQNTSSSLT LIRIVIFQQP MLKDFHSSMQ
EREATDPKEK GGFWSNVGHR LKSLFGSESF DYKQEDEVFD IETKEVEPAV FHICGASQAK
VDAAKKKIND LMSNEQCQEE IIDNDILNLS SADCQRIVDI QMKMSVSIKK QSTNGQTSFI
IEGLSKDVLR ASREIDNMLK KVRQEQELKK KLELAATVAD WQYQQHGLSY QSFDQMTNYE
LEHALERATP TLKVTIHGSD YTVQMPKGPA TDGKGTKLQI RRIDKLKDED VPEFWDAMPA
GKTCHSVILQ TASSEYAEVL NLFKATCNRA VIKIERIQNP TLWKSLQIKK HEMEVRNNHQ
NNEKRLFHGT SENTVPIINE RGFNRSYAGK NAACYGNGSY FAVNSNYSAQ DTYSRPNAKG
EKFMYLCKVL TGDYTLGQQT MIAPPTKGTL GIYDSVVDNT TTPSMFVVFH DTQAYPEYLI
TFK
//
