ID M3ZZD0_XIPMA Unreviewed; 421 AA.
AC M3ZZD0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=inositol-polyphosphate 5-phosphatase {ECO:0000256|ARBA:ARBA00012997};
DE EC=3.1.3.56 {ECO:0000256|ARBA:ARBA00012997};
GN Name=INPP5A {ECO:0000313|Ensembl:ENSXMAP00000007574.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007574.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007574.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007574.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type I family. {ECO:0000256|ARBA:ARBA00023599}.
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DR AlphaFoldDB; M3ZZD0; -.
DR STRING; 8083.ENSXMAP00000007574; -.
DR Ensembl; ENSXMAT00000007582.2; ENSXMAP00000007574.2; ENSXMAG00000007542.2.
DR eggNOG; KOG1976; Eukaryota.
DR GeneTree; ENSGT00390000015226; -.
DR HOGENOM; CLU_057709_1_0_1; -.
DR InParanoid; M3ZZD0; -.
DR OMA; GDHKPVM; -.
DR OrthoDB; 2898734at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR039737; INPP5A.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR12997:SF2; INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A; 1.
DR PANTHER; PTHR12997; TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 9..409
FT /note="Inositol polyphosphate-related phosphatase"
FT /evidence="ECO:0000259|SMART:SM00128"
SQ SEQUENCE 421 AA; 48818 MW; 08551046C4E3AE56 CRC64;
MMARRIAEQG AKILLVTANV GSLFEDTENL KKVWLKEFFE TVKAHKPHFL ALHCQECGGK
SLESGVTEVE RFVKELMAAQ ELKDYSRARV YIDESYESPE RFTALGSFYF IHDSLKNVSE
FDFEAGMFQK VTGKEIRTIR QQKSPMVQKE KFPADFFPQC QWSRKGFIRT RWGLSSCDFD
LVNVHLFHDA HNVVAWKESP SYYAGIRQKA MDFVLQRISD ERHKKLPFFL FGDFNFRLDA
RPLFEHLCST GTLEAITNTN NDVDKLIFRE TNNDRKVILE VERKSFNYVD PNVFQANNGT
SLLQFDKELL VFKDRLDEME ITFPPTYPYS EDVRHAKQYN TTRCPAWCDR ILMSTSAKLL
VAKPEDEREE GERENEENSI VYDNIGPNVC MGDHKPVFLS FRLPAGKGNP YACTCRCCVV
L
//
