ID M3ZZN0_XIPMA Unreviewed; 885 AA.
AC M3ZZN0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Interleukin 6 signal transducer {ECO:0000313|Ensembl:ENSXMAP00000007674.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007674.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007674.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007674.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR AlphaFoldDB; M3ZZN0; -.
DR STRING; 8083.ENSXMAP00000007674; -.
DR Ensembl; ENSXMAT00000007682.2; ENSXMAP00000007674.1; ENSXMAG00000007648.2.
DR eggNOG; ENOG502QXEG; Eukaryota.
DR GeneTree; ENSGT00940000155603; -.
DR HOGENOM; CLU_017990_0_0_1; -.
DR InParanoid; M3ZZN0; -.
DR OMA; RYILEWC; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF83; INTERLEUKIN-6 RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..885
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004047330"
FT TRANSMEM 631..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..331
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 529..623
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 312..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 98713 MW; 7434DE9A4E9382C4 CRC64;
MMSSMVLQLF GLAFVTSVLH GHEFSTHLVT APDLPVVEIG TNFTATCVIV NTVEATADNL
YWNLSESSVV PEKNYIKINE SALAVTILIS GEESEWLFCI CKKNSPYVSL NKSKFIHGIY
LKKAYPPRRV ENLSCVAEQA GKMVSNTLNC KWDVVGGQTE DAKTNYTVMV QHDSGTYRSS
TTILNTTFVD LGLFPHYMQL EVWVVAHNLL GTVESEHLKQ DANEFVKTHP PSKVTAIPEE
PFPNSLLIKW QHPIDDVRIK LTYQIRYCQS GSHAWSYIPL GDTDKVITSF RLQNLQPYSA
YVIQMRCRNR DGNSGRWSNW SANETKTTPE DRPRSKPDLW QLSGGDYGEE VQIICKDPKH
ANGRITSFGL IPYTKNGRLE QEIILADQNQ NSSESRVTLL KKISLADKQL VKVCVNANNS
KGTSPEACLG IPVRSSERPT VEELKVWTQE GQMFVEWKRP NNTGVTEYVV EWARPGKTDW
QRENKTTTRT AIKGSLEKFV RYNVSVYVIQ SGRIRKLVHR EAYLEQGAPE QGPTINKSYP
AYDNARLVWD EIPLDKRRGF ITNYNISYRK ENEAPKSIPV PANKTSYTLT GLLGNTKYEV
WISASTVAGS KNSNPHSFTT LRYAPGTIEG IVVGVSLGFL FFVLMALLLC FLKKDVLKEN
FWPQIPNPGE STIGNWSPDY PPKEETPKEN CVSGVSVLDV GVCEVKLGFE EDKTSLSLKK
GKYLSEEHSS GIGGSSCMSS PRQSVSDSDE GPDLADSTAS TVQYSSVVAS SGYKGQTPSS
HSQHSIFSRS ESTQPLLDSE EHPDVSLQEG CRQVQHPPRP SLFTGAENQN SMESDDFRLL
GVDHHDFCPL REDTELTTEP DSLSADTESA AVSSYMPQLG GYRPQ
//