ID M3ZZP8_XIPMA Unreviewed; 565 AA.
AC M3ZZP8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Neutral amino acid transporter 9 {ECO:0000256|ARBA:ARBA00040233};
DE AltName: Full=Solute carrier family 38 member 9 {ECO:0000256|ARBA:ARBA00042870};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007692.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007692.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007692.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-asparagine(out) = L-asparagine(in); Xref=Rhea:RHEA:73423,
CC ChEBI:CHEBI:58048; Evidence={ECO:0000256|ARBA:ARBA00036663};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419,
CC ChEBI:CHEBI:58359; Evidence={ECO:0000256|ARBA:ARBA00036878};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011,
CC ChEBI:CHEBI:57427; Evidence={ECO:0000256|ARBA:ARBA00036887};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine(in) = L-tyrosine(out); Xref=Rhea:RHEA:68572,
CC ChEBI:CHEBI:58315; Evidence={ECO:0000256|ARBA:ARBA00036984};
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC SLC38A9 subfamily. {ECO:0000256|ARBA:ARBA00038442}.
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DR AlphaFoldDB; M3ZZP8; -.
DR STRING; 8083.ENSXMAP00000007692; -.
DR Ensembl; ENSXMAT00000007700.2; ENSXMAP00000007692.2; ENSXMAG00000007655.2.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00390000005646; -.
DR HOGENOM; CLU_037564_0_0_1; -.
DR InParanoid; M3ZZP8; -.
DR OMA; HWFTPTE; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140785; F:amino acid sensor activity; IEA:Ensembl.
DR GO; GO:0034618; F:arginine binding; IEA:Ensembl.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:Ensembl.
DR GO; GO:0015820; P:leucine transport; IEA:Ensembl.
DR GO; GO:1900037; P:regulation of cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0006111; P:regulation of gluconeogenesis; IEA:Ensembl.
DR GO; GO:0006110; P:regulation of glycolytic process; IEA:Ensembl.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR22950:SF244; SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 9; 1.
DR Pfam; PF01490; Aa_trans; 2.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..235
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
FT DOMAIN 299..558
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 565 AA; 63471 MW; 978A65F689FC62F5 CRC64;
KSSIRSVVSH KIVSHITHRE LNELYYDGEK NSGKLQSITS VPFYVEPRNI VSNDPQERIS
AEAAILNSRV HYYSRLTGSS DTMLSPPNHV IPTPEEMYVY SPLGMAFKVP DSEQAAKNPS
IVTIFAIWNT MMGTSILSIP WGIKQAGFTL GIIILIFTGL LMLYCCYIVI KSPKAIRGVD
TSSWEFPDVC RFYFGKLGQW SSLVFSMVSL VGAMVVYWVL MSNFLYNTGQ FIYSNVIVFN
YVCGDVLLMC LPVICPYPKT HPGRNDSMTS LCGSSSGNDS SGSSFDHYWS KTGTIPLYLI
VLLLPLLCFR SASFFARFTF FGTISVIYLI VLVTIKASRL GFHLEFHWFD PSKFYVPEFR
LFFPQLTGVL TLAFFIHNCI ITLMKSNKNQ ENNVRDLSLA YLLVGGTYMY VGVLIFAAFP
SPPLSKDCIE PNFLDNFPSS DVMVFVARVC LLFQMITVYP LLGYLVRVQI MGQLFGNHYP
GFIHILVLNI LIVGAGVLMA MFYPNIGSII RFSGAICGLA LVFLLPTLVH MFSLREQGRL
TWQSVLFHSF LIVLGVANLM AQFFM
//
