ID M3ZZY0_XIPMA Unreviewed; 334 AA.
AC M3ZZY0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CDK2 associated cullin domain 1 {ECO:0000313|Ensembl:ENSXMAP00000007774.1};
GN Name=CACUL1 {ECO:0000313|Ensembl:ENSXMAP00000007774.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007774.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007774.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007774.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019}.
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DR AlphaFoldDB; M3ZZY0; -.
DR STRING; 8083.ENSXMAP00000007774; -.
DR Ensembl; ENSXMAT00000007782.2; ENSXMAP00000007774.1; ENSXMAG00000007753.2.
DR eggNOG; KOG2166; Eukaryota.
DR GeneTree; ENSGT00390000000403; -.
DR HOGENOM; CLU_062250_0_0_1; -.
DR InParanoid; M3ZZY0; -.
DR OrthoDB; 2938756at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR InterPro; IPR042652; CACUL1.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR46636; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46636:SF1; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00888; Cullin; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 117..273
FT /note="Cullin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00888"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 37351 MW; 0EEB5FFEE58FD1F6 CRC64;
MEAMEDDSSE VKDDHNHNYC GGKVRAALSS QVPDGVGAPE PVCPTVPGGE PAKRQAKPWS
GSPRGSKFMD SDTGSESSEV SEPDCSAAST EDKFRLDSTS KFLLNAMAVE DYRKNHWPNL
EEAIDRLLIQ NFSDHISVSY AQIYGYVYKC VCQQHSELLY SDLTSKISAH LQQVSTQLQA
SPTENLIENF NIALTQYLAS LQCIVPVFIY LNKFYIESKL NRDLKEDLMK LFADHVAEEH
LSKLMPLLIK AHSMPFQVQP STMASVVKGL HSLRPEWAQL APALFSSFIP QIHPPAMESQ
LLDYADCDRK LQMELSMNGF PRGDQSRKRA SEDS
//
