ID M4A0G2_XIPMA Unreviewed; 927 AA.
AC M4A0G2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSXMAP00000007956.2};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSXMAP00000007956.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007956.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007956.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007956.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; M4A0G2; -.
DR STRING; 8083.ENSXMAP00000007956; -.
DR Ensembl; ENSXMAT00000007963.2; ENSXMAP00000007956.2; ENSXMAG00000007897.2.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_014115_0_0_1; -.
DR InParanoid; M4A0G2; -.
DR OMA; MYVYVIS; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..299
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 331..463
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 551..671
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 927 AA; 107431 MW; 15C619F948828E03 CRC64;
MGSIRAFLQL TSRGMKLDRV RELGRQYPVF CFLLLLLLLT TLLLNRYIHI ILVFWSFLAG
VVTFYCSLGP ESLLPNIFMS IKPKTKQELF PLGHSCAVCG KIKCKRHRPT LLLENYQPWL
DLKIPSKVDA SLSEILELVL ENVVYPWYRE ITDDDSFVDE LRVTLRFLAA VLVRRIQKVD
VASLITRKLL KVSMKHIEII SKARQKVKNA EHLQQAALDE FGPDLHVALR SRRDELLYLR
KLTEILFPYI LPPKGTDCRS LTLLIREVLA GSVFLPSMDY LADPDTVNHL ILIFIDKTPP
EEATEPTSAL VPFLQKYSDS RNKKPSVLKL ELKEIREQQD LLFRFMNFLK QEGAVHVLQF
CLAVEEFNDR ILCPELPDSE KMMLHEEVKK IYETYCLDES IDKIRFDPFI VEEIRNIAEG
PYAQVVKLQT MRCLFEAYEH VLSLLENVFT PMFCHSDEYF RQLLRGAESP ARNSKMSRNT
SKRGESFGIS RIGSKIKGVF KSTTMEGAML PSYGLVEGED DMVEEAMMVL EDDSPMEAAS
TPSTPRNLSA WNITIPYIDF YDDDVKRERI PVFCIDVERN DRKAVGHETE HWSVYRRYLE
FYVLESKLTE FHGSFPDAQL PSKRIIGPKN YEFLTSKREE FEEYLQKLLQ HPELSNSQLL
ADFLSPHSME SQFLDKMLPD VNLGKIIKAV PSKLIKEKGQ HLEPFIQSFF NSCESPKPKP
SRPELTILSP TSENDKKLFN DLFKNNANRS EVTEKRHNQN YFMEMITVEG VYDYLMYVGR
VVFHIPDWFH HLLMGGRILI KNSLEAYTDH YLQHKLNQVV QEHRLVSLIT LLRDAVFCES
SPPRSAQDKQ SRAKRTFEEM MSYIPDFLGK CIGEEAKYEG VRLLFDGLQQ PVLNKQLTYV
LLDIVIQELF PELNKVQKEP SAVAPWM
//
