ID M4A0P0_XIPMA Unreviewed; 367 AA.
AC M4A0P0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 {ECO:0000313|Ensembl:ENSXMAP00000008034.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008034.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008034.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008034.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR RefSeq; XP_005796703.1; XM_005796646.2.
DR AlphaFoldDB; M4A0P0; -.
DR STRING; 8083.ENSXMAP00000008034; -.
DR Ensembl; ENSXMAT00000008044.2; ENSXMAP00000008034.1; ENSXMAG00000008008.2.
DR GeneID; 102234415; -.
DR KEGG; xma:102234415; -.
DR CTD; 80270; -.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000160236; -.
DR HOGENOM; CLU_007383_6_3_1; -.
DR InParanoid; M4A0P0; -.
DR OMA; GDHFKRG; -.
DR OrthoDB; 3675908at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF835; 3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 11..281
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 367 AA; 41754 MW; 7DB93DFE7F286EEE CRC64;
MAENKRTLVY LITGGCGFLG KHLLDVLLEK EEKLAEVRVF DKHTYPGFHE QRKTDEVKVT
LIQGDITDYS SVLEATRGVD VVIHSASLVD VWHKIPAFLI YSVNVTGTEN VIRACVECGV
ERLVYTSSME VIGPNVNGDH FKRGNEDTKY EVKHTMAYPK SKAKAEKVVL KANGKKLKSG
KCLYTCSLRP TGIYGEGHQL MRDFYNLAVE RGGLVIGGVP DHIEHGRVYA GNVAWMHVLA
ARALKTNPEK VGGEAFFCYD ESPYKSYEDF NMELLSEFNF RKVCMPGIVL FFLAILNDFL
RWILSPFYNY TPLLNRYTLA VASTTFTVQT DKAQRYFQYQ PLYDWNQCLA RTQSWIRTFP
TDKSKDS
//
