ID M4A1C1_XIPMA Unreviewed; 799 AA.
AC M4A1C1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cadherin 7 {ECO:0000313|Ensembl:ENSXMAP00000008265.2};
GN Name=CDH7 {ECO:0000313|Ensembl:ENSXMAP00000008265.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008265.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008265.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008265.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; M4A1C1; -.
DR STRING; 8083.ENSXMAP00000008265; -.
DR Ensembl; ENSXMAT00000008276.2; ENSXMAP00000008265.2; ENSXMAG00000008244.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000157031; -.
DR HOGENOM; CLU_005284_4_3_1; -.
DR InParanoid; M4A1C1; -.
DR OMA; WDVPHRN; -.
DR OrthoDB; 3667774at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF91; CADHERIN-7; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..799
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017405615"
FT TRANSMEM 618..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..163
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 164..272
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 273..387
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 388..492
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 492..602
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 799 AA; 87907 MW; B15F78329738673B CRC64;
MGWCCSGICR ALALLVLLFV LRGRGCCCWG LSPSSGDGEK SLRSDPDSWE ALHRNKRSWV
WNQFFVLEEY TGNEPLYVGK LHSDVDKGDG KVKYVLSGEG ATSIFTIDEN TGDIHATKRL
DREAQAYYTL QAQAIDRITN LPVEPRSEFV VKVQDINDNE PKFLDGPYLA GVPEMSPLGT
MVVQVAATDA DDPTYGNSAR VVYSIIHGQP YFSVEPKTGV IRTALPNMDR ETKDQYVLVI
QAKDMVGQMG GLSGTTSVTV TLTDVNDNPP RFAHKSYQYT VLESLPVQSV VARIKAADAD
IGSNAEMDYR IMDGDGPGMF NITTDEDTQE GVIILQKPLD FETRSGFALR IEATNRNIDS
NFLSLGPFSD ITSMKVSVAD VNEPPVFSTP LSKLNVSEDA KVGTSIGRVS AHDPDNSNSG
IRYSIDRNTD LERFFNVDAL SGIISTAKSL DREANSIHNL TILAIESLDP NQIGKGITLI
TVLDVNDNAP VFAIDYETLL CENSMPGQVI QTISAVDKDE PLDGHRFNFA LDGTVAGNLN
FTLRDNKDNT ASILTKRGGF RRREQAVYRL PVLITDNGKP TLSSTNTLSV RVCDCDSDGV
ALSCGAVAYT ATGLSTGALL AILGCIITLL VMVLLIVTMR RRRKQPLILE EERDIRENIV
RYDDEGGGEE DTEAFDMVTL RNLNIIRDPA ARRDVTPDTP TFYQYTSASR PSYKSLPDNV
VFREFIWERL KDADVDPTAP PYDSLQTYAF EGSGSVAESL SSLESLSTDS DQNYDYLSNW
GPRFKKLADL YGNSDSMFS
//
