ID M4A1J4_XIPMA Unreviewed; 724 AA.
AC M4A1J4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Heat shock protein HSP 90-alpha 1 {ECO:0000313|Ensembl:ENSXMAP00000008338.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008338.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008338.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008338.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR RefSeq; XP_005805662.1; XM_005805605.1.
DR AlphaFoldDB; M4A1J4; -.
DR STRING; 8083.ENSXMAP00000008338; -.
DR Ensembl; ENSXMAT00000008349.2; ENSXMAP00000008338.1; ENSXMAG00000008315.2.
DR GeneID; 102218377; -.
DR KEGG; xma:102218377; -.
DR eggNOG; KOG0019; Eukaryota.
DR GeneTree; ENSGT01020000230401; -.
DR HOGENOM; CLU_006684_1_3_1; -.
DR InParanoid; M4A1J4; -.
DR OMA; MSTEMET; -.
DR OrthoDB; 547579at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0050900; P:leukocyte migration; IEA:Ensembl.
DR GO; GO:0010038; P:response to metal ion; IEA:Ensembl.
DR GO; GO:0048769; P:sarcomerogenesis; IEA:Ensembl.
DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; IEA:Ensembl.
DR GO; GO:0030240; P:skeletal muscle thin filament assembly; IEA:Ensembl.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR PANTHER; PTHR11528:SF122; HEAT SHOCK PROTEIN HSP 90-ALPHA 1; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 36..190
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 225..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..724
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 83344 MW; BEDF24E32CA54612 CRC64;
MPEKAGHVME EEVETFAFQA EIAQLMSLII NTFYSNKEIF LRELISNSSD ALDKIRYESL
TDPSRLESCK ELKIEIRPDL HARTLTLIDT GIGMTKADLI NNLGTIAKSG TKAFMEALQA
GADISMIGQF GVGFYSAYLV AEKVTVITKH NDDEQYVWES AAGGSFTVRP DNGEPLGRGT
KVILHLKEDQ TEYCEEKRIK EVVKKHSQFI GYPITLFVEK TREKEVDLDE GEKEEEVEKD
AAENKDKPKI EDVGSDEDED SKDGQNKRKK KVKEKYIDAQ ELNKTKPIWT RNPDDITNEE
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFVPRRAA FDLFENKRKR NNIKLYVRRV
FIMDNCEELI PEYLNFIKGV VDSEDLPLNI SREMLQQSKI LKVIRKNLVK KCLELFTELS
EDKDNYKKFY EQFSKNIKLG IHEDSQNRKK LSDLLRFYTS ASGDEMVSIK DYVSRMKDNQ
KHIYYITGET KDQVANSAFV ERLRKAGLEV IYMIEPIDEY CVQQLKEYDG KNLVSVTKEG
LELPEDEDEK KKHEELKNKF ENLCKIMKDI LDKKIEKVVV SNRLVASPCC IVTSTYGWTA
NMERIMKSQA LRDNSTMGYM TAKKHLEINP LHPIIETLRE KAEADKNDKA VKDLVILLFE
TALLSSGFTL EDPQTHANRI YRMIKLGLGI DDDDSAVEDL IQPADEDMPV LEGDDDTSRM
EEVD
//
