ID M4A3D9_XIPMA Unreviewed; 686 AA.
AC M4A3D9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Growth arrest specific 2 like 3 {ECO:0000313|Ensembl:ENSXMAP00000008983.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008983.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008983.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008983.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAS2 family.
CC {ECO:0000256|ARBA:ARBA00038441}.
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DR RefSeq; XP_014327611.1; XM_014472125.1.
DR AlphaFoldDB; M4A3D9; -.
DR STRING; 8083.ENSXMAP00000008983; -.
DR Ensembl; ENSXMAT00000008997.2; ENSXMAP00000008983.2; ENSXMAG00000008963.2.
DR GeneID; 102230404; -.
DR KEGG; xma:102230404; -.
DR CTD; 283431; -.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000159389; -.
DR HOGENOM; CLU_025484_1_1_1; -.
DR InParanoid; M4A3D9; -.
DR OMA; YCTCPDQ; -.
DR OrthoDB; 1361287at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0021923; P:cell proliferation in hindbrain ventricular zone; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR PANTHER; PTHR46756:SF7; GAS2-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR46756; TRANSGELIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF02187; GAS2; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00243; GAS2; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51460; GAR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 56..177
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 218..290
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 305..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 73769 MW; FE9DDF8582C25307 CRC64;
MAVQTGIQVW FSEKFDAPLL SPRCPRSPLA QRHGPGLSNV FQYDQWLAVR HEATLVPMQE
DLAIWLSGML GEEVRAELFM EELDNGVKLC QLIGALQTKV AQTCPSALPK LFPTRKVACK
RDASPGSFFA RDNTANFLAW CRHVGVDNTY LFESEGLVLH KEPRQVCLCL LEVGRIVSRY
GVEPPVLVKL EKEIELEETL LMTEEPPAAV KTFSVCCQHG ALYQPEELSM DDPPCNCSNK
VSIEYLSEGR YRLGDKTIFI RMLHGKHVMV RVGGGWDTLR GFLTKYDPLR VLQFTTLEQK
ILAFQKGPPG LGGHRANNAP PPPPHMDPLA AVNGLISSSA SSSSSCSSSA SAPPVGQSCR
SYVPSPACTP ILARKGSAAV PKKDLQTVPS SPRKPTQLPL PVPTKGSSSL PSSPVSSSCR
WSPSPGSHRR ALTPSAPPVE PSSASKLKPR PHGPSAHPRS PVCPEPSSKC PKPSSPCTSP
TTEHMPRSTT VPAPRDIKPP SGASQRSHLA QRRSGSPASR LRLGTIRKAR VATRTVPVQK
TVPRQFPSPC SQAGSSRAPT PCSQAGSSRA PTPCSQAVSP ATVISICSMS KVKIKVASAI
PGPVPSIPSS SSKGNQKAPP TAQRTVRKPA APGNPSTKTA LKPEATITQP TTSQRNPVKA
AEKIPQSKTR SDKPYFEMTT RRKQRA
//