ID M4A4F7_XIPMA Unreviewed; 758 AA.
AC M4A4F7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN Name=AMPD3 {ECO:0000313|Ensembl:ENSXMAP00000009351.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009351.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000009351.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009351.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
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DR RefSeq; XP_005812169.1; XM_005812112.1.
DR AlphaFoldDB; M4A4F7; -.
DR STRING; 8083.ENSXMAP00000009351; -.
DR Ensembl; ENSXMAT00000009365.2; ENSXMAP00000009351.2; ENSXMAG00000009317.2.
DR GeneID; 102236532; -.
DR KEGG; xma:102236532; -.
DR CTD; 556578; -.
DR eggNOG; KOG1096; Eukaryota.
DR GeneTree; ENSGT00950000183011; -.
DR HOGENOM; CLU_003782_4_0_1; -.
DR InParanoid; M4A4F7; -.
DR OMA; MYGNIMV; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF2; AMP DEAMINASE 3; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT REGION 93..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 87585 MW; 5B051B2F3B4E58D0 CRC64;
MPRQFPKVTL SEEEEKKQLL VEKVYASALK EEDDRDTLSM FSVSEDLPIA LQQSQDHELL
KELAEQQSSE ESLMRQSFML IRSKTLTLQI PGASDYPDSK TVTPSGSTSS SFSSVAESCP
DFQRVTISGD YCAGITLEDY EQAVRSLFKA LMLREKYSKL AYHRFCRTTS QFLRSAENLI
WDIDDEVLPD MSPCPAEGED PYSVDNIPEN LNYELKMKNG IVCVYDGGEA LINDQPTDLP
YPDLETYAID LSELLTMISD GPTKTYCHRR LNFLSSKFYL HEILNEMAEL KELKSIPHRD
FYNVRKVDTH IHAAACMPQK HLLTFIQERY KTDKDRVVLE KDGQEMTLQE VFHSLSMDAY
DLTVDSLDVH AGRQTFHRFD KFNTKYNPMG ASELREIFLK TDNYLNGEYF ARIIKEVASD
LEESKYQYAE PRLSIYGRST DEWDSLAKWF IQQKLHSPNM RWMIQVPRIY DIFKSKNLVT
NFAKVLENIF LPLFKATVNP QTHKELHIFL KYVSGFDSVD DETKHSNHMF SYRSPKPEQW
TTRDNPPYSY YIFYMYGNIM VLNNLRKERG LNTFQFRPHC GEAGSITHLV SAFLTADNIS
HGLNLKKSPV LQYLYYLAQI PIAMSPLSNN SLFLEYSKNP LREFLHKGLC VSLSTDDPMQ
FHYTKEPLME EYAIAAQLWK LSTCDVCEIA RNSVLQSGLS HQEKKHFLGV NYLKDGHEGN
DIRRTNVAQI RMAYRHETLC NELSFIADAV KSEATNSH
//
