ID M4A572_XIPMA Unreviewed; 902 AA.
AC M4A572;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Zinc fingers and homeoboxes protein 3-like {ECO:0000313|Ensembl:ENSXMAP00000009616.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009616.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000009616.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009616.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR AlphaFoldDB; M4A572; -.
DR STRING; 8083.ENSXMAP00000009616; -.
DR Ensembl; ENSXMAT00000009630.2; ENSXMAP00000009616.2; ENSXMAG00000009597.2.
DR eggNOG; ENOG502R1SJ; Eukaryota.
DR GeneTree; ENSGT00950000182893; -.
DR HOGENOM; CLU_009147_0_0_1; -.
DR InParanoid; M4A572; -.
DR OMA; AQQVNHI; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 286..329
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 717..767
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 288..330
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 719..768
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 411..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 98645 MW; 3D9A7F39E7549D35 CRC64;
MASKRKSTVP CMIPSKSKHA REEIVLGSLP ELLPTIPEDS ILSISGEESA HFSHSSSKSE
SSSKTQKGGT YSCVTCRFES RDLNYFLDHM HNCHLDFRAQ PTFYCLNCGV SVVRFEALAL
HNANAHPKIM EGLVTASLSV NKRDGVTTVE QSLFTDSGED YKESGISLTK TPIAKMMKAK
GEHKKIVVSH TVEVRKIDTG KDADPSLLNN VPELQNGALS TSGTPAMPRT TVTHVIKTVS
NQVFHQHTPP LYSPTSSDAN KDLPKVMIPL SSIPTYDAAM DTSSFLKTSF GKFPYPTKAE
LCYLTVVSEF PEEQIKLWFT AQRLKQGISW SPEEIEEARR KMFNTVFQGG APQKQPVTAQ
QVNHIVTHHT VTGLPGSKGP NFQMAKVPYG GIKPRPVGVI TTQANLSTKP HVTRVSYSSP
VAPPKFPSTA RTTQEPTKST ELTVDQEKSN GLDEAGSSGC VNSTSSSQSS SCSSITNGVE
SRKSVNDNSN PTDTTNSVAA CSTNTSNNSE HCVADTNSES STKCSSLPTG SEGSNSATDS
ATSQVIIDNT SKSKTNCNNH HSSFIVCDPD GAHADRADDE NSHIHKTNSS SISGENCSST
CDDSIQNKNN ASKPSTESTS TTVITTSNSS IIDEGGCNKD FPMKGMSILQ KLIKEEDLII
GERAQKELRV DPIKINFKRL KMNEPQTTSD TVHQEPKCDI EVSACHTSFS PPWGNKTPQQ
LQILRQAFSN TRWPSSLQYE ELSIQTGLPK SEVVRWFSDS RYSHKNGQLK WLEIYQRPPA
ESDNARSYGD IEAESQKDPS PAKKKLIEQE TIKHPEGKAG LDLGQRLMWQ DSYEPLLALT
GSETGGRKHD KPEESGQTAV LQDPWSEGGD EQQQPTASHS LIEQQADTNQ ARDRLRMELL
EV
//
