ID M4A657_XIPMA Unreviewed; 2347 AA.
AC M4A657;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ankyrin repeat and KH domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000009951.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009951.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000009951.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009951.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000009951; -.
DR Ensembl; ENSXMAT00000009965.2; ENSXMAP00000009951.2; ENSXMAG00000009881.2.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4369; Eukaryota.
DR GeneTree; ENSGT00940000153768; -.
DR HOGENOM; CLU_000590_0_1_1; -.
DR InParanoid; M4A657; -.
DR OMA; EDCEMQK; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR CDD; cd22503; KH-I_ANKHD1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 8.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047374; KH-I_ANKHD1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF7; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 19.
DR PROSITE; PS50088; ANK_REPEAT; 19.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 354..386
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 387..419
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 420..452
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 453..485
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 517..549
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 550..582
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 609..641
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1007..1039
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1040..1072
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1074..1106
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1107..1139
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1142..1174
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1176..1208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1209..1241
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1244..1276
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1277..1309
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1624..1694
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1712..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1827..2105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2240..2279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 745..817
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 846..875
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1519..1609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1717..1763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2078..2105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2347 AA; 246350 MW; 9D96173582FFE219 CRC64;
MLTDGFEDEI DSVTPRSPVA GMGVGATPGG VGLGGIGIGV GGKKVRLYGE PGGPAAERLD
FKLAAAAVLS SSGPGSGSDE DEVSEVESFI LDQEDLDNPI MKTASELLLS SATDGVDLRT
VDPETQARLE ALLEAAGIGK LSTADGKAFA DPEVLRRLTS SVSCALDEAA AALTRMRAEN
TLNAGQADNR SLAEACSDGD VNAVRKLLDE GRSVNEHTEE GESLLCLACS AGYYELAQVL
LAMHANVEDR GIKGDITPLM AAASGGYVDI VKLLLVHGAD VNAQSSTGNT ALTYACAGGF
VDVVKVLLKE GANIEDHNEN GHTPLMEAAS AGHVEVARIL LEYGAGINTH SNEFKESALT
LACYKGHLDM VRFLLEAGAD QEHKTDEMHT ALMEACMDGH VEVARLLLDS GAQVNMPADS
FESPLTLAAC GGHVELAALL IERGANLEEV NDEGYTPLME AAREGHEEMV ALLLAQGANI
NAQTEETQET ALTLACCGGF LEVADFLIKA GADIELGCST PLMEAAQEGH LELVKYLLAA
GANVHATTAT GDTALTYACE NGHTDVADVL LQAGANLVPQ EVLGLPINSV VLFFFSCSGA
NVNRATANND HTVVSLACAG GHLAVVELLL AHGADPTHRL KDGSTMLIEA AKGGHTNVVS
YLLDYPNNIL SVPAPDLSQL TPPSQDASQV PRVPFQALAM VVPPQEPDRA PSTALQPGVP
SAVSRGPEAE ALPPFHLCPP LECIVEETEG KLNELGQRIS AIEKAQLQSL ELIQGEPLTK
DKIEELKKSR EEQVQKKKKI LKELQKVERQ LQLKTQQQFT KEYMEAKGLK EDQEAGQNQG
PGPGDGPQLP QQPPLPPSPQ TQPQPPPPPL QAAFVPIQPL PDYNPADYPG STSPELQRVL
VGQQMLGQQM LGQQPQSQGQ QLAGLGPGMI PQPAPDGLMV ATPAQTLTDT LDDIMAAVSS
RVPMLTTTTS PTPLSQPPTQ TNPNIASPPS VLPLYPSVDI DAHTESNHDT ALTLACAGGH
EELVSVLIAR QANIEHRDKK GFTPLILAAT AGHVGVVEVL LDKGGDIEAQ SERTKDTPLS
LACSGGRQEV VELLLLRGAN KEHRNVSDYT PLSLAASGGY VNIIKILLNA GAEINSRTGS
KLGISPLMLA AMNGHVPAVK LLLDMGSDIN AQIETNRNTA LTLACFQGRA EVVSLLLDRK
ANVEHRAKTG LTPLMEAASG GYAEVGRVLL DKGADVNAPP VPSSRDTALT IAADKGHYKF
CELLINRGAH IDVRNKKGNT PLWLAANGGH FDVVQLLVHA SADVDAADNR KITPLMAAFR
KGHVKVVQYL VKEVNQFPSD IECMRYIATI ADKELLKKCH QCMETIVKAK DQQAAEANKN
ASILLKELDL EKVILLRPPM NSRKQGLSYS LVSNSLGRRA RSRQKEVPIE PPSATTTTTI
GISATSTTFT TAFGKKRASV ATTPNTNRKN KKNKTKDSAP NEPIILQDPQ VALAQHKADK
NKIHGEPRGG GGGVTGGNSD SDPLDSTDCA SESSSSGGKS QELNYLPDLT SSASSSSSSS
SSSSSSSVPS SGATQSQTLI DSSSNSLPSP FKTMALPVTS PNSKLSLTSP KRGQKREEGW
KEVVRRSKKL SVPASVVSRI MGRGGCNITA IQDVTGAHID VDKQKDKNGE RMITIRGGTE
STRYAVQLIN SLIQDPAKEL EDLIPRNHIR APGSKAASAS FPNTTGTTSG SATGPKPLSS
LVASSGVSFQ PTSSTSSPSS QPGGKIGKGL PSNVRQPFPV SLPLAYAHPQ LALLAAQTMH
QIRHPRLPMA QFGGTFSPAA STWGPFPVRP VSPGSANGSP KHNGGANNTQ AKPSSTHGEH
NSTASSGTAV TTTNTMTTSV PNTSASSPHT PNPAPYNLQP SIPTPSSVRK QLFAPDPKPA
GVTPVSNSAA TSVSNAVRGT GSTAHPTSTT TTANAPQQQV GPISQPPIQP TKTEPAPVAP
AGKDKPSAPE CQPASVSESF TSPALALGTK PEPRPPASSG PSTEAHPPLH NSQPGSGLPP
GTSPAHSHNV AHPNNTVPHF SSSAPRVSHR MQPPGPYYHP EQQQQSVFPT NLPPQPQTQG
QAPSSLQVSA NLGMINGSQH IASAGKPQQI SANFGPAGLF NFSTIFDNNN QVGNNQVWGA
CHLPARSPPE QSYSAPPAYM NISQMENMMP PPPPESSKAP GYRSASQRMV NSPIALTSYA
TSISGSPVYL HGHTGVGTPS FSRQHFSPHP WSASTSAVAS PPQPKPGSSS QQDRKVPPPI
GTERLARIRQ TGSVNPPLLT TSYTASVGQG GIWSFGVGNA SGENCSWNFA NPYHRLQCGM
GAIHQIG
//
